Dynamic Shuttling of TIA-1 Accompanies the Recruitment of mRNA to Mammalian Stress Granules

Mammalian stress granules (SGs) harbor untranslated mRNAs that accumulate in cells exposed to environmental stress. Drugs that stabilize polysomes (emetine) inhibit the assembly of SGs, whereas drugs that destabilize polysomes (puromycin) promote the assembly of SGs. Moreover, emetine dissolves pref...

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Veröffentlicht in:	The Journal of cell biology 2000-12, Vol.151 (6), p.1257-1268
Hauptverfasser:	Kedersha, Nancy, Cho, Michael R., Li, Wei, Yacono, Patrick W., Chen, Samantha, Gilks, Natalie, Golan, David E., Anderson, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arsenites Cells COS Cells Cytoplasmic Granules - metabolism emetine Emetine - pharmacology Fluorescence Genetics Image Processing, Computer-Assisted Male Mammals Membrane Proteins - metabolism Messenger RNA Microscopy, Fluorescence Original Oxidative stress PABP protein Pharmaceuticals Phosphorylation Poly(A)-Binding Proteins Polyribosomes Polyribosomes - metabolism Prostatic Neoplasms Protein Biosynthesis Protein synthesis Proteins puromycin Puromycin - pharmacology Ribonucleic acid RNA RNA, Messenger, Stored - metabolism RNA-Binding Proteins - metabolism stress granules Stress, Physiological - metabolism TIA-1 protein Tumor Cells, Cultured
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