Taking The Time To Study Competitive Antagonism

Selective receptor antagonists are one of the most powerful resources in a pharmacologist's toolkit and are essential for the identification and classification of receptor subtypes and dissecting their roles in normal and abnormal body function. However, when the actions of antagonists are meas...

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Veröffentlicht in:	British journal of pharmacology 2007-03, Vol.150 (5), p.541-551
Hauptverfasser:	Wyllie, D J A, Chen, P E
Format:	Artikel
Sprache:	eng
Schlagworte:	agonist Animals antagonist binding Binding, Competitive Biological and medical sciences Computer Simulation Dose-Response Relationship, Drug Drug Evaluation, Preclinical - methods D‐AP5 equilibrium constant Excitatory Amino Acid Agonists - metabolism Excitatory Amino Acid Agonists - pharmacology Excitatory Amino Acid Antagonists - metabolism Excitatory Amino Acid Antagonists - pharmacology gating Humans inhibition Ion Channel Gating - drug effects Ion Channels - agonists Ion Channels - antagonists & inhibitors Ion Channels - genetics Ion Channels - metabolism Kinetics Ligands Medical sciences Models, Biological Nicotinic Agonists - metabolism Nicotinic Agonists - pharmacology Nicotinic Antagonists - metabolism Nicotinic Antagonists - pharmacology NVP‐AAM077 Pharmacology. Drug treatments Point Mutation Protein Binding Receptors, Cell Surface - agonists Receptors, Cell Surface - antagonists & inhibitors Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, Nicotinic - drug effects Reproducibility of Results Reviews Schild analysis Synaptic Transmission - drug effects
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