Involvement of Na+–Ca2+ exchanger in cAMP‐mediated relaxation in mice aorta: Evaluation using transgenic mice

Background and purpose: Although vascular smooth muscle cells are known to express the Na+–Ca2+ exchanger (NCX), its functional role has remained unclear, mainly because of its relatively low expression. We thus investigated the involvement of NCX in the mechanism for the forskolin‐induced vaso‐rela...

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Veröffentlicht in:	British journal of pharmacology 2007-02, Vol.150 (4), p.434-444
Hauptverfasser:	Karashima, E, Nishimura, J, Iwamoto, T, Hirano, K, Hirano, M, Kita, S, Harada, M, Kanaide, H
Format:	Artikel
Sprache:	eng
Schlagworte:	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology Aniline Compounds - pharmacology Animals Aorta - cytology Aorta - drug effects Aorta, Thoracic - cytology Aorta, Thoracic - drug effects Biological and medical sciences Calcium - metabolism cAMP Colforsin - antagonists & inhibitors Colforsin - pharmacology Cyclic AMP - physiology Dinoprost - pharmacology Dogs Fluorescent Dyes Fluorometry Fura-2 - analogs & derivatives Male Medical sciences Mice Mice, Inbred C57BL Mice, Transgenic Muscle Contraction - drug effects Muscle Contraction - physiology Muscle Relaxation - physiology Muscle, Smooth, Vascular - physiology Na+–Ca2+ exchanger Pharmacology. Drug treatments Phenyl Ethers - pharmacology Research Papers Sodium - physiology Sodium-Calcium Exchanger - genetics Sodium-Calcium Exchanger - physiology transgenic mouse Vasoconstrictor Agents - pharmacology
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