Xenogeneic skin graft rejection is especially dependent on CD4+ T cells

B6 mice were treated in vivo with anti-CD4, anti-CD8, or both anti-T cell antibodies together in an effort to prolong xenogeneic compared with allogeneic skin graft survival. Mice treated with anti-CD4 antibody showed prolonged survival of xenogeneic monkey or rabbit skin even after they had rejecte...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of experimental medicine 1989-09, Vol.170 (3), p.991-996
Hauptverfasser:	Pierson, 3rd, R N, Winn, H J, Russell, P S, Auchincloss, Jr, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Differentiation, T-Lymphocyte - physiology CD8 Antigens Graft Rejection Graft Survival Histocompatibility Antigens - physiology Macaca mulatta Mice Mice, Inbred BALB C Mice, Inbred C57BL Rabbits Skin Transplantation T-Lymphocytes - immunology Transplantation, Heterologous
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page	996
container_issue	3
container_start_page	991
container_title	The Journal of experimental medicine
container_volume	170
creator	Pierson, 3rd, R N Winn, H J Russell, P S Auchincloss, Jr, H
description	B6 mice were treated in vivo with anti-CD4, anti-CD8, or both anti-T cell antibodies together in an effort to prolong xenogeneic compared with allogeneic skin graft survival. Mice treated with anti-CD4 antibody showed prolonged survival of xenogeneic monkey or rabbit skin even after they had rejected whole MHC-disparate allogeneic mouse skin. Furthermore, the addition of cyclosporine was synergistic with the anti-CD4 antibody in prolonging graft survival. These results suggest that the cell-mediated response to xenogeneic antigens is especially dependent on CD4+ lymphocytes, a feature shared by the response to allogeneic minor histocompatibility antigens. In addition, the results suggest a possible approach to clinical immunosuppression for some forms of xenogeneic transplantation.
doi_str_mv	10.1084/jem.170.3.991
format	Article
fullrecord	<record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2189433</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79178322</sourcerecordid><originalsourceid>FETCH-LOGICAL-c382t-3033c57e7e1e4df57f483599406b21b848cbf41d9cbd15714ec6a3959d7b6e063</originalsourceid><addsrcrecordid>eNpVkE1LAzEQhoMotVaPHoWcvMjWZJNskosgVatQ8FLBW9jNztbU_TLZCv33prSInubwPrwz8yB0ScmUEsVv19BMqSRTNtWaHqExFZwkWjB1jMaEpGlCCZGn6CyENSGUc5GN0CgVhCupx2j-Dm23ghacxeHTtXjl82rAHtZgB9e12AUMoQfr8rre4hJ6aEtoBxyj2QO_wUtsoa7DOTqp8jrAxWFO0NvT43L2nCxe5y-z-0VimUqHhBHGrJAggQIvKyErrpjQmpOsSGmhuLJFxWmpbVFSISkHm-VMC13KIgOSsQm62_f2m6KB0sZTfF6b3rsm91vT5c78T1r3YVbdt0mp0pyxWHB9KPDd1wbCYBoXdi_kLXSbYKSmUrE0jWCyB63vQvBQ_S6hxOzMm2jeRPOGmWg-8ld_L_ulD6rZD9Mvf1M</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79178322</pqid></control><display><type>article</type><title>Xenogeneic skin graft rejection is especially dependent on CD4+ T cells</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Pierson, 3rd, R N ; Winn, H J ; Russell, P S ; Auchincloss, Jr, H</creator><creatorcontrib>Pierson, 3rd, R N ; Winn, H J ; Russell, P S ; Auchincloss, Jr, H</creatorcontrib><description>B6 mice were treated in vivo with anti-CD4, anti-CD8, or both anti-T cell antibodies together in an effort to prolong xenogeneic compared with allogeneic skin graft survival. Mice treated with anti-CD4 antibody showed prolonged survival of xenogeneic monkey or rabbit skin even after they had rejected whole MHC-disparate allogeneic mouse skin. Furthermore, the addition of cyclosporine was synergistic with the anti-CD4 antibody in prolonging graft survival. These results suggest that the cell-mediated response to xenogeneic antigens is especially dependent on CD4+ lymphocytes, a feature shared by the response to allogeneic minor histocompatibility antigens. In addition, the results suggest a possible approach to clinical immunosuppression for some forms of xenogeneic transplantation.</description><identifier>ISSN: 0022-1007</identifier><identifier>EISSN: 1540-9538</identifier><identifier>DOI: 10.1084/jem.170.3.991</identifier><identifier>PMID: 2504879</identifier><language>eng</language><publisher>United States: The Rockefeller University Press</publisher><subject>Animals ; Antigens, Differentiation, T-Lymphocyte - physiology ; CD8 Antigens ; Graft Rejection ; Graft Survival ; Histocompatibility Antigens - physiology ; Macaca mulatta ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Rabbits ; Skin Transplantation ; T-Lymphocytes - immunology ; Transplantation, Heterologous</subject><ispartof>The Journal of experimental medicine, 1989-09, Vol.170 (3), p.991-996</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-3033c57e7e1e4df57f483599406b21b848cbf41d9cbd15714ec6a3959d7b6e063</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2504879$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pierson, 3rd, R N</creatorcontrib><creatorcontrib>Winn, H J</creatorcontrib><creatorcontrib>Russell, P S</creatorcontrib><creatorcontrib>Auchincloss, Jr, H</creatorcontrib><title>Xenogeneic skin graft rejection is especially dependent on CD4+ T cells</title><title>The Journal of experimental medicine</title><addtitle>J Exp Med</addtitle><description>B6 mice were treated in vivo with anti-CD4, anti-CD8, or both anti-T cell antibodies together in an effort to prolong xenogeneic compared with allogeneic skin graft survival. Mice treated with anti-CD4 antibody showed prolonged survival of xenogeneic monkey or rabbit skin even after they had rejected whole MHC-disparate allogeneic mouse skin. Furthermore, the addition of cyclosporine was synergistic with the anti-CD4 antibody in prolonging graft survival. These results suggest that the cell-mediated response to xenogeneic antigens is especially dependent on CD4+ lymphocytes, a feature shared by the response to allogeneic minor histocompatibility antigens. In addition, the results suggest a possible approach to clinical immunosuppression for some forms of xenogeneic transplantation.</description><subject>Animals</subject><subject>Antigens, Differentiation, T-Lymphocyte - physiology</subject><subject>CD8 Antigens</subject><subject>Graft Rejection</subject><subject>Graft Survival</subject><subject>Histocompatibility Antigens - physiology</subject><subject>Macaca mulatta</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>Rabbits</subject><subject>Skin Transplantation</subject><subject>T-Lymphocytes - immunology</subject><subject>Transplantation, Heterologous</subject><issn>0022-1007</issn><issn>1540-9538</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1LAzEQhoMotVaPHoWcvMjWZJNskosgVatQ8FLBW9jNztbU_TLZCv33prSInubwPrwz8yB0ScmUEsVv19BMqSRTNtWaHqExFZwkWjB1jMaEpGlCCZGn6CyENSGUc5GN0CgVhCupx2j-Dm23ghacxeHTtXjl82rAHtZgB9e12AUMoQfr8rre4hJ6aEtoBxyj2QO_wUtsoa7DOTqp8jrAxWFO0NvT43L2nCxe5y-z-0VimUqHhBHGrJAggQIvKyErrpjQmpOsSGmhuLJFxWmpbVFSISkHm-VMC13KIgOSsQm62_f2m6KB0sZTfF6b3rsm91vT5c78T1r3YVbdt0mp0pyxWHB9KPDd1wbCYBoXdi_kLXSbYKSmUrE0jWCyB63vQvBQ_S6hxOzMm2jeRPOGmWg-8ld_L_ulD6rZD9Mvf1M</recordid><startdate>19890901</startdate><enddate>19890901</enddate><creator>Pierson, 3rd, R N</creator><creator>Winn, H J</creator><creator>Russell, P S</creator><creator>Auchincloss, Jr, H</creator><general>The Rockefeller University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19890901</creationdate><title>Xenogeneic skin graft rejection is especially dependent on CD4+ T cells</title><author>Pierson, 3rd, R N ; Winn, H J ; Russell, P S ; Auchincloss, Jr, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-3033c57e7e1e4df57f483599406b21b848cbf41d9cbd15714ec6a3959d7b6e063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Animals</topic><topic>Antigens, Differentiation, T-Lymphocyte - physiology</topic><topic>CD8 Antigens</topic><topic>Graft Rejection</topic><topic>Graft Survival</topic><topic>Histocompatibility Antigens - physiology</topic><topic>Macaca mulatta</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C57BL</topic><topic>Rabbits</topic><topic>Skin Transplantation</topic><topic>T-Lymphocytes - immunology</topic><topic>Transplantation, Heterologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pierson, 3rd, R N</creatorcontrib><creatorcontrib>Winn, H J</creatorcontrib><creatorcontrib>Russell, P S</creatorcontrib><creatorcontrib>Auchincloss, Jr, H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of experimental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pierson, 3rd, R N</au><au>Winn, H J</au><au>Russell, P S</au><au>Auchincloss, Jr, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Xenogeneic skin graft rejection is especially dependent on CD4+ T cells</atitle><jtitle>The Journal of experimental medicine</jtitle><addtitle>J Exp Med</addtitle><date>1989-09-01</date><risdate>1989</risdate><volume>170</volume><issue>3</issue><spage>991</spage><epage>996</epage><pages>991-996</pages><issn>0022-1007</issn><eissn>1540-9538</eissn><abstract>B6 mice were treated in vivo with anti-CD4, anti-CD8, or both anti-T cell antibodies together in an effort to prolong xenogeneic compared with allogeneic skin graft survival. Mice treated with anti-CD4 antibody showed prolonged survival of xenogeneic monkey or rabbit skin even after they had rejected whole MHC-disparate allogeneic mouse skin. Furthermore, the addition of cyclosporine was synergistic with the anti-CD4 antibody in prolonging graft survival. These results suggest that the cell-mediated response to xenogeneic antigens is especially dependent on CD4+ lymphocytes, a feature shared by the response to allogeneic minor histocompatibility antigens. In addition, the results suggest a possible approach to clinical immunosuppression for some forms of xenogeneic transplantation.</abstract><cop>United States</cop><pub>The Rockefeller University Press</pub><pmid>2504879</pmid><doi>10.1084/jem.170.3.991</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
fulltext	fulltext
identifier	ISSN: 0022-1007
ispartof	The Journal of experimental medicine, 1989-09, Vol.170 (3), p.991-996
issn	0022-1007 1540-9538
language	eng
recordid	cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2189433
source	MEDLINE; EZB-FREE-00999 freely available EZB journals
subjects	Animals Antigens, Differentiation, T-Lymphocyte - physiology CD8 Antigens Graft Rejection Graft Survival Histocompatibility Antigens - physiology Macaca mulatta Mice Mice, Inbred BALB C Mice, Inbred C57BL Rabbits Skin Transplantation T-Lymphocytes - immunology Transplantation, Heterologous
title	Xenogeneic skin graft rejection is especially dependent on CD4+ T cells
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T14%3A11%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Xenogeneic%20skin%20graft%20rejection%20is%20especially%20dependent%20on%20CD4+%20T%20cells&rft.jtitle=The%20Journal%20of%20experimental%20medicine&rft.au=Pierson,%203rd,%20R%20N&rft.date=1989-09-01&rft.volume=170&rft.issue=3&rft.spage=991&rft.epage=996&rft.pages=991-996&rft.issn=0022-1007&rft.eissn=1540-9538&rft_id=info:doi/10.1084/jem.170.3.991&rft_dat=%3Cproquest_pubme%3E79178322%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=79178322&rft_id=info:pmid/2504879&rfr_iscdi=true