Regulation of autoimmunity and donor cell engraftment by recipient Lyt-2+ cells during the graft-versus-host reaction
When lymphocytes from DBA/2 mice are transferred to (C57BL X DBA/2)F1 (BDF1) mice, the ensuing graft-vs.-host reaction (GVHR) causes an autoimmune illness resembling human SLE. To examine the role of recipient T cells in this process, BDF1 mice were depleted of L3T4+ or Lyt-2+ cells by thymectomy fo...
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| Veröffentlicht in: | The Journal of experimental medicine 1987-09, Vol.166 (3), p.657-667 |
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| container_title | The Journal of experimental medicine |
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| creator | HARPER, S. E ROUBINIAN, J. R SEAMAN, W. E |
| description | When lymphocytes from DBA/2 mice are transferred to (C57BL X DBA/2)F1 (BDF1) mice, the ensuing graft-vs.-host reaction (GVHR) causes an autoimmune illness resembling human SLE. To examine the role of recipient T cells in this process, BDF1 mice were depleted of L3T4+ or Lyt-2+ cells by thymectomy followed by treatment with mAbs to L3T4 or Lyt-2. This produced sustained depletion of these T cell subsets. Subsequent grafting with parental DBA/2 lymphocytes produced autoimmune disease in mice depleted of L3T4+ cells and controls but not in mice depleted of Lyt-2+ cells. Analysis of blood lymphocytes 4 wk after donor cell transfer demonstrated that BDF1 recipients depleted of Lyt-2+ cells were virtually repopulated with donor T lymphocytes, compared with less than or equal to 35% donor cell engraftment in all other groups. Thus, recipient Lyt-2+ cells influence both host cell engraftment and autoimmunity during the parent-into-F1 GVHR. |
| doi_str_mv | 10.1084/jem.166.3.657 |
| format | Article |
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Thus, recipient Lyt-2+ cells influence both host cell engraftment and autoimmunity during the parent-into-F1 GVHR.</description><identifier>ISSN: 0022-1007</identifier><identifier>EISSN: 1540-9538</identifier><identifier>DOI: 10.1084/jem.166.3.657</identifier><identifier>PMID: 2957456</identifier><identifier>CODEN: JEMEAV</identifier><language>eng</language><publisher>New York, NY: Rockefeller University Press</publisher><subject>Animals ; Applied sciences ; Autoantibodies - immunology ; Autoimmune Diseases - immunology ; Exact sciences and technology ; Female ; Graft vs Host Reaction ; Mice ; Mice, Inbred C57BL ; Mice, Inbred DBA ; Other techniques and industries ; T-Lymphocytes - transplantation ; T-Lymphocytes, Cytotoxic - immunology ; T-Lymphocytes, Helper-Inducer - immunology ; T-Lymphocytes, Regulatory - immunology ; Thymectomy</subject><ispartof>The Journal of experimental medicine, 1987-09, Vol.166 (3), p.657-667</ispartof><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-edef4588d98e586f8373affe6a78ba5d7f0d6e2a04e5047dad641f464d15912d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7845234$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2957456$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HARPER, S. E</creatorcontrib><creatorcontrib>ROUBINIAN, J. R</creatorcontrib><creatorcontrib>SEAMAN, W. E</creatorcontrib><title>Regulation of autoimmunity and donor cell engraftment by recipient Lyt-2+ cells during the graft-versus-host reaction</title><title>The Journal of experimental medicine</title><addtitle>J Exp Med</addtitle><description>When lymphocytes from DBA/2 mice are transferred to (C57BL X DBA/2)F1 (BDF1) mice, the ensuing graft-vs.-host reaction (GVHR) causes an autoimmune illness resembling human SLE. To examine the role of recipient T cells in this process, BDF1 mice were depleted of L3T4+ or Lyt-2+ cells by thymectomy followed by treatment with mAbs to L3T4 or Lyt-2. This produced sustained depletion of these T cell subsets. Subsequent grafting with parental DBA/2 lymphocytes produced autoimmune disease in mice depleted of L3T4+ cells and controls but not in mice depleted of Lyt-2+ cells. Analysis of blood lymphocytes 4 wk after donor cell transfer demonstrated that BDF1 recipients depleted of Lyt-2+ cells were virtually repopulated with donor T lymphocytes, compared with less than or equal to 35% donor cell engraftment in all other groups. Thus, recipient Lyt-2+ cells influence both host cell engraftment and autoimmunity during the parent-into-F1 GVHR.</description><subject>Animals</subject><subject>Applied sciences</subject><subject>Autoantibodies - immunology</subject><subject>Autoimmune Diseases - immunology</subject><subject>Exact sciences and technology</subject><subject>Female</subject><subject>Graft vs Host Reaction</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred DBA</subject><subject>Other techniques and industries</subject><subject>T-Lymphocytes - transplantation</subject><subject>T-Lymphocytes, Cytotoxic - immunology</subject><subject>T-Lymphocytes, Helper-Inducer - immunology</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>Thymectomy</subject><issn>0022-1007</issn><issn>1540-9538</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc1rGzEQxUVpSJ2kxx4LOpReyrrSrr58KZTQpgFDoTRnIa9GtsKu5Ooj4P--cmJMe9KI95s3MzyE3lGypESxz48wL6kQy2EpuHyFFpQz0q34oF6jBSF931FC5Bt0lfMjIZQxLi7RZb_islULVH_Btk6m-BhwdNjUEv081-DLAZtgsY0hJjzCNGEI22RcmSEUvDngBKPf--NnfShd_-kZytjW5MMWlx3gZ7x7gpRr7nYxl9ZjxuOoG3ThzJTh7em9Rg_fv_2-_dGtf97d335ddyOjtHRgwTGulF0p4Eo4NcjBOAfCSLUx3EpHrIDeEAacMGmNFYw6JpilfEV7O1yjLy---7qZwY5t22QmvU9-Numgo_H6fyX4nd7GJ91TpSShzeDjySDFPxVy0bPPx0NNgFizllIIQeTQwO4FHFPMOYE7D6FEH3PSLSfdctKDbjk1_v2_m53pUzBN_3DSTR7N5JIJo89nTCrG-4ENfwF37576</recordid><startdate>19870901</startdate><enddate>19870901</enddate><creator>HARPER, S. E</creator><creator>ROUBINIAN, J. R</creator><creator>SEAMAN, W. E</creator><general>Rockefeller University Press</general><general>The Rockefeller University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19870901</creationdate><title>Regulation of autoimmunity and donor cell engraftment by recipient Lyt-2+ cells during the graft-versus-host reaction</title><author>HARPER, S. E ; ROUBINIAN, J. R ; SEAMAN, W. E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-edef4588d98e586f8373affe6a78ba5d7f0d6e2a04e5047dad641f464d15912d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Applied sciences</topic><topic>Autoantibodies - immunology</topic><topic>Autoimmune Diseases - immunology</topic><topic>Exact sciences and technology</topic><topic>Female</topic><topic>Graft vs Host Reaction</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred DBA</topic><topic>Other techniques and industries</topic><topic>T-Lymphocytes - transplantation</topic><topic>T-Lymphocytes, Cytotoxic - immunology</topic><topic>T-Lymphocytes, Helper-Inducer - immunology</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><topic>Thymectomy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HARPER, S. E</creatorcontrib><creatorcontrib>ROUBINIAN, J. R</creatorcontrib><creatorcontrib>SEAMAN, W. E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of experimental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HARPER, S. E</au><au>ROUBINIAN, J. R</au><au>SEAMAN, W. E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulation of autoimmunity and donor cell engraftment by recipient Lyt-2+ cells during the graft-versus-host reaction</atitle><jtitle>The Journal of experimental medicine</jtitle><addtitle>J Exp Med</addtitle><date>1987-09-01</date><risdate>1987</risdate><volume>166</volume><issue>3</issue><spage>657</spage><epage>667</epage><pages>657-667</pages><issn>0022-1007</issn><eissn>1540-9538</eissn><coden>JEMEAV</coden><abstract>When lymphocytes from DBA/2 mice are transferred to (C57BL X DBA/2)F1 (BDF1) mice, the ensuing graft-vs.-host reaction (GVHR) causes an autoimmune illness resembling human SLE. To examine the role of recipient T cells in this process, BDF1 mice were depleted of L3T4+ or Lyt-2+ cells by thymectomy followed by treatment with mAbs to L3T4 or Lyt-2. This produced sustained depletion of these T cell subsets. Subsequent grafting with parental DBA/2 lymphocytes produced autoimmune disease in mice depleted of L3T4+ cells and controls but not in mice depleted of Lyt-2+ cells. Analysis of blood lymphocytes 4 wk after donor cell transfer demonstrated that BDF1 recipients depleted of Lyt-2+ cells were virtually repopulated with donor T lymphocytes, compared with less than or equal to 35% donor cell engraftment in all other groups. Thus, recipient Lyt-2+ cells influence both host cell engraftment and autoimmunity during the parent-into-F1 GVHR.</abstract><cop>New York, NY</cop><pub>Rockefeller University Press</pub><pmid>2957456</pmid><doi>10.1084/jem.166.3.657</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0022-1007 |
| ispartof | The Journal of experimental medicine, 1987-09, Vol.166 (3), p.657-667 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Applied sciences Autoantibodies - immunology Autoimmune Diseases - immunology Exact sciences and technology Female Graft vs Host Reaction Mice Mice, Inbred C57BL Mice, Inbred DBA Other techniques and industries T-Lymphocytes - transplantation T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Regulatory - immunology Thymectomy |
| title | Regulation of autoimmunity and donor cell engraftment by recipient Lyt-2+ cells during the graft-versus-host reaction |
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