Enhancement of human basophil histamine release by interleukin 5
Substantial evidence indicates a close relationship between eosinophils and basophils. We examined whether interleukin 5 (IL-5), known to be eosinophilopoietic and capable of selectively regulating eosinophil functions, has an affect on basophil functions. IL-5 enhanced basophil histamine release ev...
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| Veröffentlicht in: | The Journal of experimental medicine 1990-11, Vol.172 (5), p.1525-1528 |
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| container_end_page | 1528 |
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| container_issue | 5 |
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| container_title | The Journal of experimental medicine |
| container_volume | 172 |
| creator | HIRAI, K YAMAGUCHI, M MISAKI, Y TAKAISHI, T OHTA, K MORITA, Y ITO, K MIYAMOTO, T |
| description | Substantial evidence indicates a close relationship between eosinophils and basophils. We examined whether interleukin 5 (IL-5), known to be eosinophilopoietic and capable of selectively regulating eosinophil functions, has an affect on basophil functions. IL-5 enhanced basophil histamine release evoked by anti-IgE, formyl-methionyl-leucyl-phenylalanine, or ionophore A23187 at picomolar concentrations. Direct action of IL-5 on human basophils was confirmed using highly purified basophil populations. These observations reveal the novel fact that IL-5 is able to modulate basophil functions as well as eosinophil functions, and suggest that normal human basophils possess functional receptors for IL-5. |
| doi_str_mv | 10.1084/jem.172.5.1525 |
| format | Article |
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We examined whether interleukin 5 (IL-5), known to be eosinophilopoietic and capable of selectively regulating eosinophil functions, has an affect on basophil functions. IL-5 enhanced basophil histamine release evoked by anti-IgE, formyl-methionyl-leucyl-phenylalanine, or ionophore A23187 at picomolar concentrations. Direct action of IL-5 on human basophils was confirmed using highly purified basophil populations. These observations reveal the novel fact that IL-5 is able to modulate basophil functions as well as eosinophil functions, and suggest that normal human basophils possess functional receptors for IL-5.</description><identifier>ISSN: 0022-1007</identifier><identifier>EISSN: 1540-9538</identifier><identifier>DOI: 10.1084/jem.172.5.1525</identifier><identifier>PMID: 1700056</identifier><identifier>CODEN: JEMEAV</identifier><language>eng</language><publisher>New York, NY: Rockefeller University Press</publisher><subject>Analysis of the immune response. Humoral and cellular immunity ; Basophils - drug effects ; Basophils - metabolism ; Biological and medical sciences ; Calcimycin - pharmacology ; Dose-Response Relationship, Drug ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Histamine - metabolism ; Histamine Release - drug effects ; Humans ; Immunobiology ; Interleukin-5 - pharmacology ; Lymphokines, interleukins ( function, expression) ; N-Formylmethionine Leucyl-Phenylalanine - pharmacology ; Regulatory factors and their cellular receptors</subject><ispartof>The Journal of experimental medicine, 1990-11, Vol.172 (5), p.1525-1528</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-da72f99e47e787f7f5593392e160299f68fb39c66d42549faa56b7a63c33ae3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19508468$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1700056$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HIRAI, K</creatorcontrib><creatorcontrib>YAMAGUCHI, M</creatorcontrib><creatorcontrib>MISAKI, Y</creatorcontrib><creatorcontrib>TAKAISHI, T</creatorcontrib><creatorcontrib>OHTA, K</creatorcontrib><creatorcontrib>MORITA, Y</creatorcontrib><creatorcontrib>ITO, K</creatorcontrib><creatorcontrib>MIYAMOTO, T</creatorcontrib><title>Enhancement of human basophil histamine release by interleukin 5</title><title>The Journal of experimental medicine</title><addtitle>J Exp Med</addtitle><description>Substantial evidence indicates a close relationship between eosinophils and basophils. We examined whether interleukin 5 (IL-5), known to be eosinophilopoietic and capable of selectively regulating eosinophil functions, has an affect on basophil functions. IL-5 enhanced basophil histamine release evoked by anti-IgE, formyl-methionyl-leucyl-phenylalanine, or ionophore A23187 at picomolar concentrations. Direct action of IL-5 on human basophils was confirmed using highly purified basophil populations. These observations reveal the novel fact that IL-5 is able to modulate basophil functions as well as eosinophil functions, and suggest that normal human basophils possess functional receptors for IL-5.</description><subject>Analysis of the immune response. Humoral and cellular immunity</subject><subject>Basophils - drug effects</subject><subject>Basophils - metabolism</subject><subject>Biological and medical sciences</subject><subject>Calcimycin - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Histamine - metabolism</subject><subject>Histamine Release - drug effects</subject><subject>Humans</subject><subject>Immunobiology</subject><subject>Interleukin-5 - pharmacology</subject><subject>Lymphokines, interleukins ( function, expression)</subject><subject>N-Formylmethionine Leucyl-Phenylalanine - pharmacology</subject><subject>Regulatory factors and their cellular receptors</subject><issn>0022-1007</issn><issn>1540-9538</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1v1DAQhi0EKkvhyg0pF3pL8PfHBYGqFipV4gB3a5IdE5fEWeykUv89rnZF4TSH951nRg8hbxntGLXywx3OHTO8Ux1TXD0jO6YkbZ0S9jnZUcp5yyg1L8mrUu4oZVIqfUbOmKGUKr0jn67SCGnAGdPaLKEZtxlS00NZDmOcmjGWFeaYsMk4IRRs-ocmphXzhNuvmBr1mrwIMBV8c5rn5Pv11Y_Lr-3tty83l59v20FatrZ7MDw4h9KgsSaYoJQTwnFkmnLngrahF27Qei-5ki4AKN0b0GIQAlCck49H6mHrZ9wP9dsMkz_kOEN-8AtE_3-S4uh_LveeM2u1pRVwcQLk5feGZfVzLANOEyRctuItpdZJYWuxOxaHvJSSMfw9wqh_NO6rcV-Ne-UfjdeFd_--9lQ_Kq75-1MOZYAp5Ko7lqeaUxWqrfgDSAeKHA</recordid><startdate>19901101</startdate><enddate>19901101</enddate><creator>HIRAI, K</creator><creator>YAMAGUCHI, M</creator><creator>MISAKI, Y</creator><creator>TAKAISHI, T</creator><creator>OHTA, K</creator><creator>MORITA, Y</creator><creator>ITO, K</creator><creator>MIYAMOTO, T</creator><general>Rockefeller University Press</general><general>The Rockefeller University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19901101</creationdate><title>Enhancement of human basophil histamine release by interleukin 5</title><author>HIRAI, K ; YAMAGUCHI, M ; MISAKI, Y ; TAKAISHI, T ; OHTA, K ; MORITA, Y ; ITO, K ; MIYAMOTO, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-da72f99e47e787f7f5593392e160299f68fb39c66d42549faa56b7a63c33ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Analysis of the immune response. Humoral and cellular immunity</topic><topic>Basophils - drug effects</topic><topic>Basophils - metabolism</topic><topic>Biological and medical sciences</topic><topic>Calcimycin - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Histamine - metabolism</topic><topic>Histamine Release - drug effects</topic><topic>Humans</topic><topic>Immunobiology</topic><topic>Interleukin-5 - pharmacology</topic><topic>Lymphokines, interleukins ( function, expression)</topic><topic>N-Formylmethionine Leucyl-Phenylalanine - pharmacology</topic><topic>Regulatory factors and their cellular receptors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HIRAI, K</creatorcontrib><creatorcontrib>YAMAGUCHI, M</creatorcontrib><creatorcontrib>MISAKI, Y</creatorcontrib><creatorcontrib>TAKAISHI, T</creatorcontrib><creatorcontrib>OHTA, K</creatorcontrib><creatorcontrib>MORITA, Y</creatorcontrib><creatorcontrib>ITO, K</creatorcontrib><creatorcontrib>MIYAMOTO, T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of experimental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HIRAI, K</au><au>YAMAGUCHI, M</au><au>MISAKI, Y</au><au>TAKAISHI, T</au><au>OHTA, K</au><au>MORITA, Y</au><au>ITO, K</au><au>MIYAMOTO, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhancement of human basophil histamine release by interleukin 5</atitle><jtitle>The Journal of experimental medicine</jtitle><addtitle>J Exp Med</addtitle><date>1990-11-01</date><risdate>1990</risdate><volume>172</volume><issue>5</issue><spage>1525</spage><epage>1528</epage><pages>1525-1528</pages><issn>0022-1007</issn><eissn>1540-9538</eissn><coden>JEMEAV</coden><abstract>Substantial evidence indicates a close relationship between eosinophils and basophils. We examined whether interleukin 5 (IL-5), known to be eosinophilopoietic and capable of selectively regulating eosinophil functions, has an affect on basophil functions. IL-5 enhanced basophil histamine release evoked by anti-IgE, formyl-methionyl-leucyl-phenylalanine, or ionophore A23187 at picomolar concentrations. Direct action of IL-5 on human basophils was confirmed using highly purified basophil populations. These observations reveal the novel fact that IL-5 is able to modulate basophil functions as well as eosinophil functions, and suggest that normal human basophils possess functional receptors for IL-5.</abstract><cop>New York, NY</cop><pub>Rockefeller University Press</pub><pmid>1700056</pmid><doi>10.1084/jem.172.5.1525</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0022-1007 |
| ispartof | The Journal of experimental medicine, 1990-11, Vol.172 (5), p.1525-1528 |
| issn | 0022-1007 1540-9538 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Analysis of the immune response. Humoral and cellular immunity Basophils - drug effects Basophils - metabolism Biological and medical sciences Calcimycin - pharmacology Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Fundamental immunology Histamine - metabolism Histamine Release - drug effects Humans Immunobiology Interleukin-5 - pharmacology Lymphokines, interleukins ( function, expression) N-Formylmethionine Leucyl-Phenylalanine - pharmacology Regulatory factors and their cellular receptors |
| title | Enhancement of human basophil histamine release by interleukin 5 |
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