HLA-DR alleles differ in their ability to present staphylococcal enterotoxins to T cells
Staphylococcal enterotoxins (SEs) have been shown to bind to major histocompatibility complex (MHC) class II proteins and stimulate T cells in a V beta-specific manner, and these V beta specificities for various SEs have been well documented in mice and humans. This study was undertaken in order to...
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| Veröffentlicht in: | The Journal of experimental medicine 1990-09, Vol.172 (3), p.709-717 |
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| container_title | The Journal of experimental medicine |
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| creator | HERMAN, A CROTEAU, G SEKALY, R.-P KAPPLER, J MARRACK, P |
| description | Staphylococcal enterotoxins (SEs) have been shown to bind to major histocompatibility complex (MHC) class II proteins and stimulate T cells in a V beta-specific manner, and these V beta specificities for various SEs have been well documented in mice and humans. This study was undertaken in order to examine the ability of human class II molecules to present SEs to human and murine T cell hybridomas. Using a panel of transfectants expressing individual HLA class II antigens, we have shown that HLA-DR alleles differ in their ability to bind and present SEs. Since the HLA-DR proteins share a common alpha chain, these results indicate that the polymorphic beta chain plays an important role in SE binding and presentation to T cells. In addition, we have shown that human class II isotypes markedly differ in their ability to present SEs. The results of this study should provide information on the region of MHC class II molecules that interacts with foreign, and perhaps self, super-antigens. |
| doi_str_mv | 10.1084/jem.172.3.709 |
| format | Article |
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This study was undertaken in order to examine the ability of human class II molecules to present SEs to human and murine T cell hybridomas. Using a panel of transfectants expressing individual HLA class II antigens, we have shown that HLA-DR alleles differ in their ability to bind and present SEs. Since the HLA-DR proteins share a common alpha chain, these results indicate that the polymorphic beta chain plays an important role in SE binding and presentation to T cells. In addition, we have shown that human class II isotypes markedly differ in their ability to present SEs. The results of this study should provide information on the region of MHC class II molecules that interacts with foreign, and perhaps self, super-antigens.</description><identifier>ISSN: 0022-1007</identifier><identifier>EISSN: 1540-9538</identifier><identifier>DOI: 10.1084/jem.172.3.709</identifier><identifier>PMID: 2117633</identifier><identifier>CODEN: JEMEAV</identifier><language>eng</language><publisher>New York, NY: Rockefeller University Press</publisher><subject>Alleles ; Animals ; Antigens ; Biological and medical sciences ; Cell Line ; Enterotoxins - immunology ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Genes, MHC Class II ; Histocompatibility antigens (hla, h-2 and other systems) ; Histocompatibility Antigens Class II - genetics ; Histocompatibility Antigens Class II - immunology ; HLA-DR Antigens - genetics ; HLA-DR Antigens - immunology ; Humans ; Mice ; Molecular immunology ; Staphylococcus ; Staphylococcus - immunology ; T-Lymphocytes - immunology ; Transfection</subject><ispartof>The Journal of experimental medicine, 1990-09, Vol.172 (3), p.709-717</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-6c14bdb67fc1f4dc2d19d26f7a3b9ba16c20a3d1898639150bbb3681482b4633</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19729779$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2117633$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HERMAN, A</creatorcontrib><creatorcontrib>CROTEAU, G</creatorcontrib><creatorcontrib>SEKALY, R.-P</creatorcontrib><creatorcontrib>KAPPLER, J</creatorcontrib><creatorcontrib>MARRACK, P</creatorcontrib><title>HLA-DR alleles differ in their ability to present staphylococcal enterotoxins to T cells</title><title>The Journal of experimental medicine</title><addtitle>J Exp Med</addtitle><description>Staphylococcal enterotoxins (SEs) have been shown to bind to major histocompatibility complex (MHC) class II proteins and stimulate T cells in a V beta-specific manner, and these V beta specificities for various SEs have been well documented in mice and humans. This study was undertaken in order to examine the ability of human class II molecules to present SEs to human and murine T cell hybridomas. Using a panel of transfectants expressing individual HLA class II antigens, we have shown that HLA-DR alleles differ in their ability to bind and present SEs. Since the HLA-DR proteins share a common alpha chain, these results indicate that the polymorphic beta chain plays an important role in SE binding and presentation to T cells. In addition, we have shown that human class II isotypes markedly differ in their ability to present SEs. The results of this study should provide information on the region of MHC class II molecules that interacts with foreign, and perhaps self, super-antigens.</description><subject>Alleles</subject><subject>Animals</subject><subject>Antigens</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Enterotoxins - immunology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Genes, MHC Class II</subject><subject>Histocompatibility antigens (hla, h-2 and other systems)</subject><subject>Histocompatibility Antigens Class II - genetics</subject><subject>Histocompatibility Antigens Class II - immunology</subject><subject>HLA-DR Antigens - genetics</subject><subject>HLA-DR Antigens - immunology</subject><subject>Humans</subject><subject>Mice</subject><subject>Molecular immunology</subject><subject>Staphylococcus</subject><subject>Staphylococcus - immunology</subject><subject>T-Lymphocytes - immunology</subject><subject>Transfection</subject><issn>0022-1007</issn><issn>1540-9538</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1rVDEUxYModVpduhSy0d2b5iZ5-dgIpVpbGBDKLLoLSV6ek5J5GZM34vz3ZuhQdeXqwj0_Dvfcg9A7IEsgil8-hu0SJF2ypST6BVpAz0mne6ZeogUhlHZAiHyNzmt9JAQ478UZOqMAUjC2QA-3q6vu8z22KYUUKh7iOIaC44TnTYgFWxdTnA94znhXQg3TjOtsd5tDyj57bxNuq1DynH_FqR6xNfYhpfoGvRptquHtaV6g9c2X9fVtt_r29e76atV5ztncCQ_cDU7I0cPIB08H0AMVo7TMaWdBeEosG0BpJZiGnjjnmFDAFXW8JbhAn55sd3u3DYNv1xSbzK7ErS0Hk200_ypT3Jjv-aehoFQvSDP4eDIo-cc-1NlsYz0msFPI-2qkbr_U-v8g9A0FoRrYPYG-5FpLGJ-vAWKOlZlWmWmVGWZaZY1__3eEZ_rUUdM_nHRb28PHYicf6x9TLamWUrPfxLGgIA</recordid><startdate>19900901</startdate><enddate>19900901</enddate><creator>HERMAN, A</creator><creator>CROTEAU, G</creator><creator>SEKALY, R.-P</creator><creator>KAPPLER, J</creator><creator>MARRACK, P</creator><general>Rockefeller University Press</general><general>The Rockefeller University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19900901</creationdate><title>HLA-DR alleles differ in their ability to present staphylococcal enterotoxins to T cells</title><author>HERMAN, A ; CROTEAU, G ; SEKALY, R.-P ; KAPPLER, J ; MARRACK, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-6c14bdb67fc1f4dc2d19d26f7a3b9ba16c20a3d1898639150bbb3681482b4633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Alleles</topic><topic>Animals</topic><topic>Antigens</topic><topic>Biological and medical sciences</topic><topic>Cell Line</topic><topic>Enterotoxins - immunology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Genes, MHC Class II</topic><topic>Histocompatibility antigens (hla, h-2 and other systems)</topic><topic>Histocompatibility Antigens Class II - genetics</topic><topic>Histocompatibility Antigens Class II - immunology</topic><topic>HLA-DR Antigens - genetics</topic><topic>HLA-DR Antigens - immunology</topic><topic>Humans</topic><topic>Mice</topic><topic>Molecular immunology</topic><topic>Staphylococcus</topic><topic>Staphylococcus - immunology</topic><topic>T-Lymphocytes - immunology</topic><topic>Transfection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HERMAN, A</creatorcontrib><creatorcontrib>CROTEAU, G</creatorcontrib><creatorcontrib>SEKALY, R.-P</creatorcontrib><creatorcontrib>KAPPLER, J</creatorcontrib><creatorcontrib>MARRACK, P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of experimental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HERMAN, A</au><au>CROTEAU, G</au><au>SEKALY, R.-P</au><au>KAPPLER, J</au><au>MARRACK, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HLA-DR alleles differ in their ability to present staphylococcal enterotoxins to T cells</atitle><jtitle>The Journal of experimental medicine</jtitle><addtitle>J Exp Med</addtitle><date>1990-09-01</date><risdate>1990</risdate><volume>172</volume><issue>3</issue><spage>709</spage><epage>717</epage><pages>709-717</pages><issn>0022-1007</issn><eissn>1540-9538</eissn><coden>JEMEAV</coden><abstract>Staphylococcal enterotoxins (SEs) have been shown to bind to major histocompatibility complex (MHC) class II proteins and stimulate T cells in a V beta-specific manner, and these V beta specificities for various SEs have been well documented in mice and humans. This study was undertaken in order to examine the ability of human class II molecules to present SEs to human and murine T cell hybridomas. Using a panel of transfectants expressing individual HLA class II antigens, we have shown that HLA-DR alleles differ in their ability to bind and present SEs. Since the HLA-DR proteins share a common alpha chain, these results indicate that the polymorphic beta chain plays an important role in SE binding and presentation to T cells. In addition, we have shown that human class II isotypes markedly differ in their ability to present SEs. The results of this study should provide information on the region of MHC class II molecules that interacts with foreign, and perhaps self, super-antigens.</abstract><cop>New York, NY</cop><pub>Rockefeller University Press</pub><pmid>2117633</pmid><doi>10.1084/jem.172.3.709</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of experimental medicine, 1990-09, Vol.172 (3), p.709-717 |
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| subjects | Alleles Animals Antigens Biological and medical sciences Cell Line Enterotoxins - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology Genes, MHC Class II Histocompatibility antigens (hla, h-2 and other systems) Histocompatibility Antigens Class II - genetics Histocompatibility Antigens Class II - immunology HLA-DR Antigens - genetics HLA-DR Antigens - immunology Humans Mice Molecular immunology Staphylococcus Staphylococcus - immunology T-Lymphocytes - immunology Transfection |
| title | HLA-DR alleles differ in their ability to present staphylococcal enterotoxins to T cells |
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