Immunoprotective Leishmania major synthetic T cell epitopes
Using the predictive algorithm of Rothbard and Taylor (1988. EMBO J. 7:93) and the primary structure of gp63 (Button, L., and M.R. McMaster. 1988. J. Exp. Med. 167:724; Miller, R.A., S.G. Reed, and M. Parsons. 1990. Mol. Biochem. Parasitol. 39:267) we have been able to delineate the structures of a...
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| Veröffentlicht in: | The Journal of experimental medicine 1990-08, Vol.172 (2), p.645-648 |
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| creator | JARDIM, A ALEXANDER, J HUNG SIA TEH OU, D OLAFSON, R. W |
| description | Using the predictive algorithm of Rothbard and Taylor (1988. EMBO J. 7:93) and the primary structure of gp63 (Button, L., and M.R. McMaster. 1988. J. Exp. Med. 167:724; Miller, R.A., S.G. Reed, and M. Parsons. 1990. Mol. Biochem. Parasitol. 39:267) we have been able to delineate the structures of a number of gp63 T-cell epitopes which stimulate the proliferation of CD4+ cells. One of these synthetic antigens, inoculated subcutaneously with adjuvant, was shown to specifically induce proliferation of the Th1 subset and provided immunoprotection against two species of Leishmania parasites. |
| doi_str_mv | 10.1084/jem.172.2.645 |
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Psychology ; Interleukins - biosynthesis ; Invertebrates ; Leishmania tropica - immunology ; Leishmaniasis - immunology ; Lymphocyte Activation - drug effects ; Mice ; Molecular Sequence Data ; Peptides - chemical synthesis ; Peptides - immunology ; Peptides - pharmacology ; Protozoa ; T-Lymphocytes - drug effects ; T-Lymphocytes - immunology</subject><ispartof>The Journal of experimental medicine, 1990-08, Vol.172 (2), p.645-648</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-33e89ee3c8e20825eba701a3eb1907f4400255e8706aab394908bcf4ae0876163</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19383119$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1695670$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>JARDIM, A</creatorcontrib><creatorcontrib>ALEXANDER, J</creatorcontrib><creatorcontrib>HUNG SIA TEH</creatorcontrib><creatorcontrib>OU, D</creatorcontrib><creatorcontrib>OLAFSON, R. W</creatorcontrib><title>Immunoprotective Leishmania major synthetic T cell epitopes</title><title>The Journal of experimental medicine</title><addtitle>J Exp Med</addtitle><description>Using the predictive algorithm of Rothbard and Taylor (1988. EMBO J. 7:93) and the primary structure of gp63 (Button, L., and M.R. McMaster. 1988. J. Exp. Med. 167:724; Miller, R.A., S.G. Reed, and M. Parsons. 1990. Mol. Biochem. Parasitol. 39:267) we have been able to delineate the structures of a number of gp63 T-cell epitopes which stimulate the proliferation of CD4+ cells. One of these synthetic antigens, inoculated subcutaneously with adjuvant, was shown to specifically induce proliferation of the Th1 subset and provided immunoprotection against two species of Leishmania parasites.</description><subject>Algorithms</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Antigens, Protozoan - genetics</subject><subject>Antigens, Protozoan - immunology</subject><subject>Biochemistry. Physiology. Immunology. Molecular biology</subject><subject>Biological and medical sciences</subject><subject>CD4 Antigens - immunology</subject><subject>Cytotoxicity, Immunologic</subject><subject>Epitopes - immunology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Interleukins - biosynthesis</subject><subject>Invertebrates</subject><subject>Leishmania tropica - immunology</subject><subject>Leishmaniasis - immunology</subject><subject>Lymphocyte Activation - drug effects</subject><subject>Mice</subject><subject>Molecular Sequence Data</subject><subject>Peptides - chemical synthesis</subject><subject>Peptides - immunology</subject><subject>Peptides - pharmacology</subject><subject>Protozoa</subject><subject>T-Lymphocytes - drug effects</subject><subject>T-Lymphocytes - immunology</subject><issn>0022-1007</issn><issn>1540-9538</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rGzEQhkVpcB2nxxwDe2lv644-VyJQCKZJDYZcnLPQqrO1zO5qK60D-fddY9Okp8xh5vA-DDM8hFxTWFLQ4tseuyWt2JItlZAfyJxKAaWRXH8kcwDGSgpQfSKXOe8BqBBSzciMKiNVBXNyu-66Qx-HFEf0Y3jGYoMh7zrXB1d0bh9TkV_6cYdj8MW28Ni2BQ5hjAPmK3LRuDbj5_NckKf7H9vVz3Lz-LBe3W1KLwQfS85RG0TuNTLQTGLtKqCOY00NVI0Q05VSoq5AOVdzIwzo2jfCIehKUcUX5Ptp73CoO_zlsR-Ta-2QQufSi40u2P-TPuzs7_hsGdWaT7UgX88LUvxzwDzaLuTjK67HeMi2Mtowzui7IJVaKSaOYHkCfYo5J2z-XUPBHrXYSYudtFhmJy0Tf_P2hVf65GHKv5xzl71rm-R6H_IrZrjmdOp_ATWqlgs</recordid><startdate>19900801</startdate><enddate>19900801</enddate><creator>JARDIM, A</creator><creator>ALEXANDER, J</creator><creator>HUNG SIA TEH</creator><creator>OU, D</creator><creator>OLAFSON, R. 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| subjects | Algorithms Amino Acid Sequence Animals Antigens, Protozoan - genetics Antigens, Protozoan - immunology Biochemistry. Physiology. Immunology. Molecular biology Biological and medical sciences CD4 Antigens - immunology Cytotoxicity, Immunologic Epitopes - immunology Fundamental and applied biological sciences. Psychology Interleukins - biosynthesis Invertebrates Leishmania tropica - immunology Leishmaniasis - immunology Lymphocyte Activation - drug effects Mice Molecular Sequence Data Peptides - chemical synthesis Peptides - immunology Peptides - pharmacology Protozoa T-Lymphocytes - drug effects T-Lymphocytes - immunology |
| title | Immunoprotective Leishmania major synthetic T cell epitopes |
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