Anti-threonyl-tRNA synthetase, a second myositis-related autoantibody

An autoantibody known as PL-7 was found in the serum of four patients with myositis and one with a systemic lupus erythematosus-like syndrome. The PL-7 antigen is an 80,000 dalton polypeptide that coprecipitates with transfer RNA. In aminoacylation reactions, PL-7 IgG inhibited the charging of tRNA...

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Veröffentlicht in:	The Journal of experimental medicine 1984-08, Vol.160 (2), p.420-434
Hauptverfasser:	MATHEWS, M. B, REICHLIN, M, HUGHES, G. R. V, BERNSTEIN, R. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amino Acyl-tRNA Synthetases - immunology Animals Antibody Specificity Autoantibodies - analysis Autoantibodies - physiology Autoantigens - analysis Binding, Competitive Biological and medical sciences Epitopes Female Humans Male Medical sciences Middle Aged Myositis - immunology Precipitin Tests Rabbits RNA - analysis Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Threonine-tRNA Ligase - immunology Threonine-tRNA Ligase - isolation & purification
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