Ethnic differences in the lymphocyte proliferative response induced by a murine igG1 antibody, Leu-4, to the T3 molecule
The mitogenic effects of isotypically diverse antibodies to the T3 molecule were examined in genetically diverse population groups. Whereas the OKT3 antibody (IgG2a) was mitogenic for blood mononuclear cells from all individuals tested, the 38.1 antibody (IgM) was consistently nonmitogenic. In contr...
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| Veröffentlicht in: | The Journal of experimental medicine 1984-07, Vol.160 (1), p.303-309 |
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| creator | ABO, T TILDEN, A. B BALCH, C. M KUMAGAI, K TROUP, G. M COOPER, M. D |
| description | The mitogenic effects of isotypically diverse antibodies to the T3 molecule were examined in genetically diverse population groups. Whereas the OKT3 antibody (IgG2a) was mitogenic for blood mononuclear cells from all individuals tested, the 38.1 antibody (IgM) was consistently nonmitogenic. In contrast, studies of the mitogenic effects of the Leu-4 antibody (IgG1) revealed striking ethnic differences. More than 80% of Caucasians and Negroes were good Leu-4 responders, whereas most individuals of Asian origin, including Indian, Japanese, and Chinese, were either Leu-4 nonresponders or Leu-4 low responders. However, the majority of American Indians, as well as a significant minority of Chinese, were good responders. Cell separation studies confirmed that monocytes govern the different mitogenic effects of the anti-T3 antibodies. The results reveal interesting ethnic differences in monocyte accessory function probably mediated via the Fc-gamma receptor, in the stimulation of T lymphocytes by an IgG1 antibody against the T3 molecule. |
| doi_str_mv | 10.1084/jem.160.1.303 |
| format | Article |
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Cell separation studies confirmed that monocytes govern the different mitogenic effects of the anti-T3 antibodies. The results reveal interesting ethnic differences in monocyte accessory function probably mediated via the Fc-gamma receptor, in the stimulation of T lymphocytes by an IgG1 antibody against the T3 molecule.</description><identifier>ISSN: 0022-1007</identifier><identifier>EISSN: 1540-9538</identifier><identifier>DOI: 10.1084/jem.160.1.303</identifier><identifier>PMID: 6429266</identifier><identifier>CODEN: JEMEAV</identifier><language>eng</language><publisher>New York, NY: Rockefeller University Press</publisher><subject>Adult ; Analysis of the immune response. 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B</creatorcontrib><creatorcontrib>BALCH, C. M</creatorcontrib><creatorcontrib>KUMAGAI, K</creatorcontrib><creatorcontrib>TROUP, G. M</creatorcontrib><creatorcontrib>COOPER, M. D</creatorcontrib><title>Ethnic differences in the lymphocyte proliferative response induced by a murine igG1 antibody, Leu-4, to the T3 molecule</title><title>The Journal of experimental medicine</title><addtitle>J Exp Med</addtitle><description>The mitogenic effects of isotypically diverse antibodies to the T3 molecule were examined in genetically diverse population groups. Whereas the OKT3 antibody (IgG2a) was mitogenic for blood mononuclear cells from all individuals tested, the 38.1 antibody (IgM) was consistently nonmitogenic. In contrast, studies of the mitogenic effects of the Leu-4 antibody (IgG1) revealed striking ethnic differences. More than 80% of Caucasians and Negroes were good Leu-4 responders, whereas most individuals of Asian origin, including Indian, Japanese, and Chinese, were either Leu-4 nonresponders or Leu-4 low responders. However, the majority of American Indians, as well as a significant minority of Chinese, were good responders. Cell separation studies confirmed that monocytes govern the different mitogenic effects of the anti-T3 antibodies. The results reveal interesting ethnic differences in monocyte accessory function probably mediated via the Fc-gamma receptor, in the stimulation of T lymphocytes by an IgG1 antibody against the T3 molecule.</description><subject>Adult</subject><subject>Analysis of the immune response. Humoral and cellular immunity</subject><subject>Antibodies, Monoclonal - physiology</subject><subject>Antigens, Differentiation, T-Lymphocyte</subject><subject>Antigens, Surface - genetics</subject><subject>Antigens, Surface - immunology</subject><subject>Biological and medical sciences</subject><subject>Black or African American</subject><subject>Black People</subject><subject>Cell interactions</subject><subject>China - ethnology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Immunobiology</subject><subject>Immunoglobulin G - physiology</subject><subject>Indians, North American</subject><subject>Japan - ethnology</subject><subject>Lymphocyte Activation</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Monocytes - immunology</subject><subject>T-Lymphocytes - immunology</subject><subject>United States</subject><subject>White People</subject><issn>0022-1007</issn><issn>1540-9538</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFrHCEYhiU0pNs0xx4LHkpPma2OjqOXQglJGljoJT2L43xmDTM61ZmQ-fe1ybK0p55E34cHv-9F6AMlW0ok__II45aKctkywk7QhjacVKph8g3aEFLXFSWkfYve5fxICOW8EWfoTPBa1UJs0PP1vA_e4t47BwmChYx9wPMe8LCO0z7adQY8pTj4kpvZPwFOkKcYMhSwXyz0uFuxweOSfChvD7cUmzD7LvbrJd7BUvFLPMcX5T3DYxzALgO8R6fODBkuDuc5-nlzfX_1vdr9uL27-rarLGv5XCniasJp10puFW0dCO7qTnSmk0axzrqupaoBKSmHWkhmHGc9bSUoZa2hnJ2jr6_eaelG6C2EOZlBT8mPJq06Gq__TYLf64f4pGsq27KlIvh8EKT4a4E869FnC8NgAsQla0lprUhL_wuW3QsiSFPA6hW0KeacwB1_Q4n-06kunerSqaa6dFr4j3-PcKQPJZb80yE32ZrBJROsz0dMtUWiBPsNitCrTA</recordid><startdate>19840701</startdate><enddate>19840701</enddate><creator>ABO, T</creator><creator>TILDEN, A. 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Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Immunobiology</topic><topic>Immunoglobulin G - physiology</topic><topic>Indians, North American</topic><topic>Japan - ethnology</topic><topic>Lymphocyte Activation</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Monocytes - immunology</topic><topic>T-Lymphocytes - immunology</topic><topic>United States</topic><topic>White People</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ABO, T</creatorcontrib><creatorcontrib>TILDEN, A. B</creatorcontrib><creatorcontrib>BALCH, C. M</creatorcontrib><creatorcontrib>KUMAGAI, K</creatorcontrib><creatorcontrib>TROUP, G. M</creatorcontrib><creatorcontrib>COOPER, M. 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| subjects | Adult Analysis of the immune response. Humoral and cellular immunity Antibodies, Monoclonal - physiology Antigens, Differentiation, T-Lymphocyte Antigens, Surface - genetics Antigens, Surface - immunology Biological and medical sciences Black or African American Black People Cell interactions China - ethnology Female Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Immunoglobulin G - physiology Indians, North American Japan - ethnology Lymphocyte Activation Male Middle Aged Monocytes - immunology T-Lymphocytes - immunology United States White People |
| title | Ethnic differences in the lymphocyte proliferative response induced by a murine igG1 antibody, Leu-4, to the T3 molecule |
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