Ultimate erythropoietic repopulating abilities of fetal, young adult, and old adult cells compared using repeated irradiation

Erythropoietic repopulating abilities of fetal liver cells and young and old adult marrow cells were compared as follows: Equal numbers of cells from a donor of each age were mixed with a constant portion of cells pooled from genetically distinguishable competitors. These mixtures were transplanted...

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Veröffentlicht in:	J. Exp. Med.; (United States) 1984-09, Vol.160 (3), p.759-771
Hauptverfasser:	HARRISON, D. E, ASTLE, C. M, LERNER, C
Format:	Artikel
Sprache:	eng
Schlagworte:	560152 - Radiation Effects on Animals- Animals AGE DEPENDENCE Aging ANIMAL CELLS Animals Biological and medical sciences BIOLOGICAL EFFECTS BIOLOGICAL RADIATION EFFECTS BLOOD FORMATION BODY BONE MARROW CELLS Bone Marrow Transplantation Cell cycle, cell proliferation Cell physiology Cell Survival - radiation effects CONNECTIVE TISSUE CELLS DIGESTIVE SYSTEM Erythrocytes - metabolism Erythrocytes - physiology ERYTHROPOIESIS Female Fetus Fundamental and applied biological sciences. Psychology GLANDS Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells - physiology Hematopoietic Stem Cells - radiation effects Hemoglobins - biosynthesis IRRADIATION LIVER Liver - cytology Male Mice Mice, Inbred C57BL Molecular and cellular biology ORGANS Pregnancy Radiation Chimera RADIATION EFFECTS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT SOMATIC CELLS STEM CELLS SUBLETHAL IRRADIATION TRANSPLANTS
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