Heterogeneity among human collagenases demonstrated by monoclonal antibody that selectively recognizes and inhibits human neutrophil collagenase

The heterogeneity of human collagenases has been examined using a monoclonal antibody to neutrophil collagenase. This antibody inhibited collagenase activity and, when covalently coupled to Sepharose, bound both latent and active enzyme. Although human neutrophil collagenase was inhibited by the ant...

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Veröffentlicht in:	The Journal of experimental medicine 1984-05, Vol.159 (5), p.1455-1463
Hauptverfasser:	HASTY, K. A, HIBBS, M. S, KANG, A. H, MAINARDI, C. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Antibodies, Monoclonal - physiology Arthritis, Rheumatoid - immunology Binding, Competitive Biological and medical sciences Cell Separation Cross Reactions Enzyme Inhibitors - physiology Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Humans Hydrolases Mice Microbial Collagenase - antagonists & inhibitors Microbial Collagenase - genetics Microbial Collagenase - immunology Microbial Collagenase - metabolism Neutrophils - enzymology Skin - enzymology Synovial Membrane - enzymology Tissue Inhibitor of Metalloproteinases
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