In vivo effects of antibodies to immune response gene products. I. Haplotype-specific suppression of humoral immune responses with a monoclonal anti-I-A

Immune response (Ir) gene products control immunologic function at several critical sites. We administered in vivo a monoclonal antibody reactive with I-Ak to F1 mice with the genotype H-2k/b. These treated mnice made a markedly reduced antibody response to antigen (H,G)-A--L, under the control of I...

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Veröffentlicht in:	The Journal of experimental medicine 1981-11, Vol.154 (5), p.1694-1702
Hauptverfasser:	Rosenbaum, J T, Adelman, N E, McDevitt, H O
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal Antibody Formation Female Freund's Adjuvant - pharmacology Genes, MHC Class II Haploidy Histocompatibility Antigens Class II - immunology Immunization, Secondary Immunosuppression Male Mice Mice, Inbred C3H Peptides - immunology Protein Biosynthesis
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