In vivo effects of antibodies to immune response gene products. I. Haplotype-specific suppression of humoral immune responses with a monoclonal anti-I-A
Immune response (Ir) gene products control immunologic function at several critical sites. We administered in vivo a monoclonal antibody reactive with I-Ak to F1 mice with the genotype H-2k/b. These treated mnice made a markedly reduced antibody response to antigen (H,G)-A--L, under the control of I...
Gespeichert in:
| Veröffentlicht in: | The Journal of experimental medicine 1981-11, Vol.154 (5), p.1694-1702 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1702 |
|---|---|
| container_issue | 5 |
| container_start_page | 1694 |
| container_title | The Journal of experimental medicine |
| container_volume | 154 |
| creator | Rosenbaum, J T Adelman, N E McDevitt, H O |
| description | Immune response (Ir) gene products control immunologic function at several critical sites. We administered in vivo a monoclonal antibody reactive with I-Ak to F1 mice with the genotype H-2k/b. These treated mnice made a markedly reduced antibody response to antigen (H,G)-A--L, under the control of I-Ak, but not to antigen (T,G)-A--L, under the control of I-Ab. This relative specificity was lost if the antigen was given in complete Freund's adjuvant rather than aqueous solution. The monoclonal antibody reduced the antibody titer in an ongoing, secondary response as well. Several potential mechanisms can be postulated for this effect. This haplotypic specificity might ultimately be relevant to human disease. |
| doi_str_mv | 10.1084/jem.154.5.1694 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2186506</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>73706625</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3314-bb447971fe4ddef794bf31772b6b7bdd870b4427d70668ccc4602197ad4926ac3</originalsourceid><addsrcrecordid>eNqFkU1r3DAQhkVpSLdpr70VdOrNrmR92ZdCCE2zEOglPQtZHmUVbEm17C35J_25kckS2l56EoOeeWaGF6EPlNSUtPzzA0w1FbwWNZUdf4V2pSBVJ1j7Gu0IaZqKEqLeoLc5PxBCORfyHJ1LVQgiduj3PuCjP0YMzoFdMo4Om7D4Pg4eMl4i9tO0BsAz5BRDBnwPpUpzHNaC13hf4xuTxrg8JqhyAuudtzivKZWO7GPYjId1irMZ_3Vl_MsvB2zwFEO0YwwF2YZX--ryHTpzZszw_vReoB_XX--ubqrb79_2V5e3lWWM8qrvOVedog74MIBTHe8do0o1vexVPwytIoVo1KCIlK21lkvS0E6ZgXeNNJZdoC_P3rT2EwwWwlI21Wn2k5kfdTRe__0T_EHfx6NuaCsFkUXw6SSY488V8qInny2MowkQ16wV20Y34r8gFYKxlm9g_QzaOeY8g3vZhhK9ha5L6AXnWugt9NLw8c8bXvBTyuwJajysLw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15533845</pqid></control><display><type>article</type><title>In vivo effects of antibodies to immune response gene products. I. Haplotype-specific suppression of humoral immune responses with a monoclonal anti-I-A</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Rosenbaum, J T ; Adelman, N E ; McDevitt, H O</creator><creatorcontrib>Rosenbaum, J T ; Adelman, N E ; McDevitt, H O</creatorcontrib><description>Immune response (Ir) gene products control immunologic function at several critical sites. We administered in vivo a monoclonal antibody reactive with I-Ak to F1 mice with the genotype H-2k/b. These treated mnice made a markedly reduced antibody response to antigen (H,G)-A--L, under the control of I-Ak, but not to antigen (T,G)-A--L, under the control of I-Ab. This relative specificity was lost if the antigen was given in complete Freund's adjuvant rather than aqueous solution. The monoclonal antibody reduced the antibody titer in an ongoing, secondary response as well. Several potential mechanisms can be postulated for this effect. This haplotypic specificity might ultimately be relevant to human disease.</description><identifier>ISSN: 0022-1007</identifier><identifier>EISSN: 1540-9538</identifier><identifier>DOI: 10.1084/jem.154.5.1694</identifier><identifier>PMID: 6795305</identifier><language>eng</language><publisher>United States: The Rockefeller University Press</publisher><subject>Animals ; Antibodies, Monoclonal ; Antibody Formation ; Female ; Freund's Adjuvant - pharmacology ; Genes, MHC Class II ; Haploidy ; Histocompatibility Antigens Class II - immunology ; Immunization, Secondary ; Immunosuppression ; Male ; Mice ; Mice, Inbred C3H ; Peptides - immunology ; Protein Biosynthesis</subject><ispartof>The Journal of experimental medicine, 1981-11, Vol.154 (5), p.1694-1702</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3314-bb447971fe4ddef794bf31772b6b7bdd870b4427d70668ccc4602197ad4926ac3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6795305$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rosenbaum, J T</creatorcontrib><creatorcontrib>Adelman, N E</creatorcontrib><creatorcontrib>McDevitt, H O</creatorcontrib><title>In vivo effects of antibodies to immune response gene products. I. Haplotype-specific suppression of humoral immune responses with a monoclonal anti-I-A</title><title>The Journal of experimental medicine</title><addtitle>J Exp Med</addtitle><description>Immune response (Ir) gene products control immunologic function at several critical sites. We administered in vivo a monoclonal antibody reactive with I-Ak to F1 mice with the genotype H-2k/b. These treated mnice made a markedly reduced antibody response to antigen (H,G)-A--L, under the control of I-Ak, but not to antigen (T,G)-A--L, under the control of I-Ab. This relative specificity was lost if the antigen was given in complete Freund's adjuvant rather than aqueous solution. The monoclonal antibody reduced the antibody titer in an ongoing, secondary response as well. Several potential mechanisms can be postulated for this effect. This haplotypic specificity might ultimately be relevant to human disease.</description><subject>Animals</subject><subject>Antibodies, Monoclonal</subject><subject>Antibody Formation</subject><subject>Female</subject><subject>Freund's Adjuvant - pharmacology</subject><subject>Genes, MHC Class II</subject><subject>Haploidy</subject><subject>Histocompatibility Antigens Class II - immunology</subject><subject>Immunization, Secondary</subject><subject>Immunosuppression</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C3H</subject><subject>Peptides - immunology</subject><subject>Protein Biosynthesis</subject><issn>0022-1007</issn><issn>1540-9538</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1r3DAQhkVpSLdpr70VdOrNrmR92ZdCCE2zEOglPQtZHmUVbEm17C35J_25kckS2l56EoOeeWaGF6EPlNSUtPzzA0w1FbwWNZUdf4V2pSBVJ1j7Gu0IaZqKEqLeoLc5PxBCORfyHJ1LVQgiduj3PuCjP0YMzoFdMo4Om7D4Pg4eMl4i9tO0BsAz5BRDBnwPpUpzHNaC13hf4xuTxrg8JqhyAuudtzivKZWO7GPYjId1irMZ_3Vl_MsvB2zwFEO0YwwF2YZX--ryHTpzZszw_vReoB_XX--ubqrb79_2V5e3lWWM8qrvOVedog74MIBTHe8do0o1vexVPwytIoVo1KCIlK21lkvS0E6ZgXeNNJZdoC_P3rT2EwwWwlI21Wn2k5kfdTRe__0T_EHfx6NuaCsFkUXw6SSY488V8qInny2MowkQ16wV20Y34r8gFYKxlm9g_QzaOeY8g3vZhhK9ha5L6AXnWugt9NLw8c8bXvBTyuwJajysLw</recordid><startdate>19811101</startdate><enddate>19811101</enddate><creator>Rosenbaum, J T</creator><creator>Adelman, N E</creator><creator>McDevitt, H O</creator><general>The Rockefeller University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19811101</creationdate><title>In vivo effects of antibodies to immune response gene products. I. Haplotype-specific suppression of humoral immune responses with a monoclonal anti-I-A</title><author>Rosenbaum, J T ; Adelman, N E ; McDevitt, H O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3314-bb447971fe4ddef794bf31772b6b7bdd870b4427d70668ccc4602197ad4926ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Animals</topic><topic>Antibodies, Monoclonal</topic><topic>Antibody Formation</topic><topic>Female</topic><topic>Freund's Adjuvant - pharmacology</topic><topic>Genes, MHC Class II</topic><topic>Haploidy</topic><topic>Histocompatibility Antigens Class II - immunology</topic><topic>Immunization, Secondary</topic><topic>Immunosuppression</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C3H</topic><topic>Peptides - immunology</topic><topic>Protein Biosynthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rosenbaum, J T</creatorcontrib><creatorcontrib>Adelman, N E</creatorcontrib><creatorcontrib>McDevitt, H O</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of experimental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rosenbaum, J T</au><au>Adelman, N E</au><au>McDevitt, H O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vivo effects of antibodies to immune response gene products. I. Haplotype-specific suppression of humoral immune responses with a monoclonal anti-I-A</atitle><jtitle>The Journal of experimental medicine</jtitle><addtitle>J Exp Med</addtitle><date>1981-11-01</date><risdate>1981</risdate><volume>154</volume><issue>5</issue><spage>1694</spage><epage>1702</epage><pages>1694-1702</pages><issn>0022-1007</issn><eissn>1540-9538</eissn><abstract>Immune response (Ir) gene products control immunologic function at several critical sites. We administered in vivo a monoclonal antibody reactive with I-Ak to F1 mice with the genotype H-2k/b. These treated mnice made a markedly reduced antibody response to antigen (H,G)-A--L, under the control of I-Ak, but not to antigen (T,G)-A--L, under the control of I-Ab. This relative specificity was lost if the antigen was given in complete Freund's adjuvant rather than aqueous solution. The monoclonal antibody reduced the antibody titer in an ongoing, secondary response as well. Several potential mechanisms can be postulated for this effect. This haplotypic specificity might ultimately be relevant to human disease.</abstract><cop>United States</cop><pub>The Rockefeller University Press</pub><pmid>6795305</pmid><doi>10.1084/jem.154.5.1694</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1007 |
| ispartof | The Journal of experimental medicine, 1981-11, Vol.154 (5), p.1694-1702 |
| issn | 0022-1007 1540-9538 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2186506 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Antibodies, Monoclonal Antibody Formation Female Freund's Adjuvant - pharmacology Genes, MHC Class II Haploidy Histocompatibility Antigens Class II - immunology Immunization, Secondary Immunosuppression Male Mice Mice, Inbred C3H Peptides - immunology Protein Biosynthesis |
| title | In vivo effects of antibodies to immune response gene products. I. Haplotype-specific suppression of humoral immune responses with a monoclonal anti-I-A |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T10%3A56%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=In%20vivo%20effects%20of%20antibodies%20to%20immune%20response%20gene%20products.%20I.%20Haplotype-specific%20suppression%20of%20humoral%20immune%20responses%20with%20a%20monoclonal%20anti-I-A&rft.jtitle=The%20Journal%20of%20experimental%20medicine&rft.au=Rosenbaum,%20J%20T&rft.date=1981-11-01&rft.volume=154&rft.issue=5&rft.spage=1694&rft.epage=1702&rft.pages=1694-1702&rft.issn=0022-1007&rft.eissn=1540-9538&rft_id=info:doi/10.1084/jem.154.5.1694&rft_dat=%3Cproquest_pubme%3E73706625%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15533845&rft_id=info:pmid/6795305&rfr_iscdi=true |