Bone marrow origin of Ia-positive cells in the medulla rat thymus
Irradiated rats were reconstituted with bone marrow from F1 hybrids. Ia antigen of donor-bone marrow origin was detected by an immunoperoxidase technique on cryostat sections and found predominantly in the medulla of rat thymus 2 wk after reconstitution. These Ia-bearing cells increased in number wi...
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| Veröffentlicht in: | J. Exp. Med.; (United States) 1981-06, Vol.153 (6), p.1666-1671 |
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| container_end_page | 1671 |
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| container_title | J. Exp. Med.; (United States) |
| container_volume | 153 |
| creator | Barclay, A N Mayrhofer, G |
| description | Irradiated rats were reconstituted with bone marrow from F1 hybrids. Ia antigen of donor-bone marrow origin was detected by an immunoperoxidase technique on cryostat sections and found predominantly in the medulla of rat thymus 2 wk after reconstitution. These Ia-bearing cells increased in number with time after reconstitution, but the Ia on the cortical epithelial cells remained of host origin. The nature of the bone marrow-derived cells and their implication for major histocompatibility complex restriction are discussed. |
| doi_str_mv | 10.1084/jem.153.6.1666 |
| format | Article |
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Ia antigen of donor-bone marrow origin was detected by an immunoperoxidase technique on cryostat sections and found predominantly in the medulla of rat thymus 2 wk after reconstitution. These Ia-bearing cells increased in number with time after reconstitution, but the Ia on the cortical epithelial cells remained of host origin. The nature of the bone marrow-derived cells and their implication for major histocompatibility complex restriction are discussed.</description><identifier>ISSN: 0022-1007</identifier><identifier>EISSN: 1540-9538</identifier><identifier>DOI: 10.1084/jem.153.6.1666</identifier><identifier>PMID: 6942092</identifier><language>eng</language><publisher>United States: The Rockefeller University Press</publisher><subject>560300 - Chemicals Metabolism & Toxicology ; ANIMAL CELLS ; ANIMAL TISSUES ; ANIMALS ; ANTIGENS ; BODY ; BONE MARROW ; Bone Marrow - immunology ; BONE MARROW CELLS ; CARBOXYLIC ACIDS ; CELL DIFFERENTIATION ; CHIMERAS ; CONNECTIVE TISSUE CELLS ; ENZYMES ; HEMATOPOIETIC SYSTEM ; HETEROCYCLIC ACIDS ; HETEROCYCLIC COMPOUNDS ; Histocompatibility Antigens Class II - analysis ; IMMUNOLOGY ; LYMPHATIC SYSTEM ; Major Histocompatibility Complex ; MAMMALS ; Mice ; MOSAICISM ; ORGANIC ACIDS ; ORGANIC COMPOUNDS ; ORGANIC NITROGEN COMPOUNDS ; ORGANS ; OXIDOREDUCTASES ; PEROXIDASES ; PORPHYRINS ; Radiation Chimera ; RADIATION CHIMERAS ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; RATS ; RODENTS ; SOMATIC CELLS ; THYMUS ; Thymus Gland - cytology ; Thymus Gland - immunology ; TISSUES ; VERTEBRATES</subject><ispartof>J. Exp. 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Med.; (United States)</title><addtitle>J Exp Med</addtitle><description>Irradiated rats were reconstituted with bone marrow from F1 hybrids. Ia antigen of donor-bone marrow origin was detected by an immunoperoxidase technique on cryostat sections and found predominantly in the medulla of rat thymus 2 wk after reconstitution. These Ia-bearing cells increased in number with time after reconstitution, but the Ia on the cortical epithelial cells remained of host origin. The nature of the bone marrow-derived cells and their implication for major histocompatibility complex restriction are discussed.</description><subject>560300 - Chemicals Metabolism & Toxicology</subject><subject>ANIMAL CELLS</subject><subject>ANIMAL TISSUES</subject><subject>ANIMALS</subject><subject>ANTIGENS</subject><subject>BODY</subject><subject>BONE MARROW</subject><subject>Bone Marrow - immunology</subject><subject>BONE MARROW CELLS</subject><subject>CARBOXYLIC ACIDS</subject><subject>CELL DIFFERENTIATION</subject><subject>CHIMERAS</subject><subject>CONNECTIVE TISSUE CELLS</subject><subject>ENZYMES</subject><subject>HEMATOPOIETIC SYSTEM</subject><subject>HETEROCYCLIC ACIDS</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>Histocompatibility Antigens Class II - analysis</subject><subject>IMMUNOLOGY</subject><subject>LYMPHATIC SYSTEM</subject><subject>Major Histocompatibility Complex</subject><subject>MAMMALS</subject><subject>Mice</subject><subject>MOSAICISM</subject><subject>ORGANIC ACIDS</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANIC NITROGEN COMPOUNDS</subject><subject>ORGANS</subject><subject>OXIDOREDUCTASES</subject><subject>PEROXIDASES</subject><subject>PORPHYRINS</subject><subject>Radiation Chimera</subject><subject>RADIATION CHIMERAS</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RATS</subject><subject>RODENTS</subject><subject>SOMATIC CELLS</subject><subject>THYMUS</subject><subject>Thymus Gland - cytology</subject><subject>Thymus Gland - immunology</subject><subject>TISSUES</subject><subject>VERTEBRATES</subject><issn>0022-1007</issn><issn>1540-9538</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtPxCAYRYnR6PjYujNpXLhr_XiWbkzU-EpM3OiaMJQ6mE4ZgWr899LMxOjKFQEOlwsHoWMMFQbJzt_sssKcVqLCQogtNMOcQdlwKrfRDICQEgPUe2g_xjcAzBgXu2hXNIxAQ2bo8soPtljqEPxn4YN7dUPhu-JBlysfXXIftjC272OR19Mik7Yd-14XQac8_1qO8RDtdLqP9mgzHqCX25vn6_vy8enu4frysTQcmlTOJQhdQ1sLzeaSSGmBCYY50ZzUQs5bRjTFHeW8la1oaEd1K42k0kArJSf0AF2sc1fjPLcwdkhB92oVXG7_pbx26u_O4Bbq1X8ogqXAjcgBp-sAH5NT0bhkzcL4YbAmKS54zckEnW1uCf59tDGppYvTD-jB-jGqmnLWAP8fzE4oB4IzWK1BE3yMwXY_lTGoSaHKCidcCTUpzAdOfj_0B984o9-MZJZh</recordid><startdate>19810601</startdate><enddate>19810601</enddate><creator>Barclay, A N</creator><creator>Mayrhofer, G</creator><general>The Rockefeller University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>OTOTI</scope><scope>5PM</scope></search><sort><creationdate>19810601</creationdate><title>Bone marrow origin of Ia-positive cells in the medulla rat thymus</title><author>Barclay, A N ; Mayrhofer, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-b806a70d76a4b8288e0464152a52768bd42a31f355d8d693f3ad8c838c0d88523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>560300 - Chemicals Metabolism & Toxicology</topic><topic>ANIMAL CELLS</topic><topic>ANIMAL TISSUES</topic><topic>ANIMALS</topic><topic>ANTIGENS</topic><topic>BODY</topic><topic>BONE MARROW</topic><topic>Bone Marrow - immunology</topic><topic>BONE MARROW CELLS</topic><topic>CARBOXYLIC ACIDS</topic><topic>CELL DIFFERENTIATION</topic><topic>CHIMERAS</topic><topic>CONNECTIVE TISSUE CELLS</topic><topic>ENZYMES</topic><topic>HEMATOPOIETIC SYSTEM</topic><topic>HETEROCYCLIC ACIDS</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>Histocompatibility Antigens Class II - analysis</topic><topic>IMMUNOLOGY</topic><topic>LYMPHATIC SYSTEM</topic><topic>Major Histocompatibility Complex</topic><topic>MAMMALS</topic><topic>Mice</topic><topic>MOSAICISM</topic><topic>ORGANIC ACIDS</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANIC NITROGEN COMPOUNDS</topic><topic>ORGANS</topic><topic>OXIDOREDUCTASES</topic><topic>PEROXIDASES</topic><topic>PORPHYRINS</topic><topic>Radiation Chimera</topic><topic>RADIATION CHIMERAS</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>RATS</topic><topic>RODENTS</topic><topic>SOMATIC CELLS</topic><topic>THYMUS</topic><topic>Thymus Gland - cytology</topic><topic>Thymus Gland - immunology</topic><topic>TISSUES</topic><topic>VERTEBRATES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barclay, A N</creatorcontrib><creatorcontrib>Mayrhofer, G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>J. Exp. Med.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barclay, A N</au><au>Mayrhofer, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone marrow origin of Ia-positive cells in the medulla rat thymus</atitle><jtitle>J. Exp. Med.; (United States)</jtitle><addtitle>J Exp Med</addtitle><date>1981-06-01</date><risdate>1981</risdate><volume>153</volume><issue>6</issue><spage>1666</spage><epage>1671</epage><pages>1666-1671</pages><issn>0022-1007</issn><eissn>1540-9538</eissn><abstract>Irradiated rats were reconstituted with bone marrow from F1 hybrids. Ia antigen of donor-bone marrow origin was detected by an immunoperoxidase technique on cryostat sections and found predominantly in the medulla of rat thymus 2 wk after reconstitution. These Ia-bearing cells increased in number with time after reconstitution, but the Ia on the cortical epithelial cells remained of host origin. The nature of the bone marrow-derived cells and their implication for major histocompatibility complex restriction are discussed.</abstract><cop>United States</cop><pub>The Rockefeller University Press</pub><pmid>6942092</pmid><doi>10.1084/jem.153.6.1666</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0022-1007 |
| ispartof | J. Exp. Med.; (United States), 1981-06, Vol.153 (6), p.1666-1671 |
| issn | 0022-1007 1540-9538 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2186196 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | 560300 - Chemicals Metabolism & Toxicology ANIMAL CELLS ANIMAL TISSUES ANIMALS ANTIGENS BODY BONE MARROW Bone Marrow - immunology BONE MARROW CELLS CARBOXYLIC ACIDS CELL DIFFERENTIATION CHIMERAS CONNECTIVE TISSUE CELLS ENZYMES HEMATOPOIETIC SYSTEM HETEROCYCLIC ACIDS HETEROCYCLIC COMPOUNDS Histocompatibility Antigens Class II - analysis IMMUNOLOGY LYMPHATIC SYSTEM Major Histocompatibility Complex MAMMALS Mice MOSAICISM ORGANIC ACIDS ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS ORGANS OXIDOREDUCTASES PEROXIDASES PORPHYRINS Radiation Chimera RADIATION CHIMERAS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RATS RODENTS SOMATIC CELLS THYMUS Thymus Gland - cytology Thymus Gland - immunology TISSUES VERTEBRATES |
| title | Bone marrow origin of Ia-positive cells in the medulla rat thymus |
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