The functional relationship of the interleukins
The mechanism of the lymphoproliferative effect of the macrophage product lymphocyte-activating factor [LAF(IL1] appears to be mediated by the stimulation of the release of T cell growth factor [TCGF(IL2)] by T cells. The magnitude of the resultant T cell proliferative clonal expansion is thus depen...
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| Veröffentlicht in: | The Journal of experimental medicine 1980-06, Vol.151 (6), p.1551-1556 |
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| container_title | The Journal of experimental medicine |
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| creator | Smith, K A Lachman, L B Oppenheim, J J Favata, M F |
| description | The mechanism of the lymphoproliferative effect of the macrophage product lymphocyte-activating factor [LAF(IL1] appears to be mediated by the stimulation of the release of T cell growth factor [TCGF(IL2)] by T cells. The magnitude of the resultant T cell proliferative clonal expansion is thus dependent upon the quantity of both LAF(IL1) and TCGF(IL2) induced by antigen or lectin stimulation. These observations, coupled with the ability to measure the production and actions of these hormone-like lymphokines, should allow for increased insight into the mode of action of immunoenhancing and immunosuppressive agents, as well as for new therapeutic approaches to disease states involving T lymphocytes. |
| doi_str_mv | 10.1084/jem.151.6.1551 |
| format | Article |
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The magnitude of the resultant T cell proliferative clonal expansion is thus dependent upon the quantity of both LAF(IL1) and TCGF(IL2) induced by antigen or lectin stimulation. 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The magnitude of the resultant T cell proliferative clonal expansion is thus dependent upon the quantity of both LAF(IL1) and TCGF(IL2) induced by antigen or lectin stimulation. These observations, coupled with the ability to measure the production and actions of these hormone-like lymphokines, should allow for increased insight into the mode of action of immunoenhancing and immunosuppressive agents, as well as for new therapeutic approaches to disease states involving T lymphocytes.</description><subject>Animals</subject><subject>Antigens</subject><subject>Cell Adhesion</subject><subject>Cell Communication</subject><subject>Glucocorticoids - pharmacology</subject><subject>Growth Substances - physiology</subject><subject>Interleukin-1</subject><subject>Interleukin-2 - physiology</subject><subject>Lectins</subject><subject>Lymphocyte Activation - drug effects</subject><subject>Lymphokines - physiology</subject><subject>Macrophages - immunology</subject><subject>Mice</subject><subject>Mice, Nude - immunology</subject><subject>Monocytes - immunology</subject><subject>Proteins - physiology</subject><subject>T-Lymphocytes - immunology</subject><issn>0022-1007</issn><issn>1540-9538</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkMtLw0AQxhdRaq1evQk5eUvcyT5zEaT4goKXel42m43dmkfdTQT_eze0FL3MDHzffDP8ELoGnAGW9G5r2wwYZDxWBidoDozitGBEnqI5xnmeAsbiHF2EsMUYKGV8hmZciKjJObpbb2xSj50ZXN_pJvG20dMYNm6X9HUyRNl1g_WNHT9dFy7RWa2bYK8OfYHenx7Xy5d09fb8unxYpYYyGNKKWGIIlFLKXHPBpazyeJnhopQ1oVhX3FgOuiAS4i9lRQtRypwXNUiGQZAFut_n7saytZWx3eB1o3betdr_qF479V_p3EZ99N8qjwGSTwG3hwDff402DKp1wdim0Z3tx6AEAwKU4WjM9kbj-xC8rY9HAKsJsYqIVUSsuJoQx4Wbv68d7Qem5BfqMXcc</recordid><startdate>19800601</startdate><enddate>19800601</enddate><creator>Smith, K A</creator><creator>Lachman, L B</creator><creator>Oppenheim, J J</creator><creator>Favata, M F</creator><general>The Rockefeller University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19800601</creationdate><title>The functional relationship of the interleukins</title><author>Smith, K A ; Lachman, L B ; Oppenheim, J J ; Favata, M F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-d3e3c31b8882a67688d2456509b8f340ad6ce61a9381677bd497b8269f1850173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Animals</topic><topic>Antigens</topic><topic>Cell Adhesion</topic><topic>Cell Communication</topic><topic>Glucocorticoids - pharmacology</topic><topic>Growth Substances - physiology</topic><topic>Interleukin-1</topic><topic>Interleukin-2 - physiology</topic><topic>Lectins</topic><topic>Lymphocyte Activation - drug effects</topic><topic>Lymphokines - physiology</topic><topic>Macrophages - immunology</topic><topic>Mice</topic><topic>Mice, Nude - immunology</topic><topic>Monocytes - immunology</topic><topic>Proteins - physiology</topic><topic>T-Lymphocytes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smith, K A</creatorcontrib><creatorcontrib>Lachman, L B</creatorcontrib><creatorcontrib>Oppenheim, J J</creatorcontrib><creatorcontrib>Favata, M F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of experimental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smith, K A</au><au>Lachman, L B</au><au>Oppenheim, J J</au><au>Favata, M F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The functional relationship of the interleukins</atitle><jtitle>The Journal of experimental medicine</jtitle><addtitle>J Exp Med</addtitle><date>1980-06-01</date><risdate>1980</risdate><volume>151</volume><issue>6</issue><spage>1551</spage><epage>1556</epage><pages>1551-1556</pages><issn>0022-1007</issn><eissn>1540-9538</eissn><abstract>The mechanism of the lymphoproliferative effect of the macrophage product lymphocyte-activating factor [LAF(IL1] appears to be mediated by the stimulation of the release of T cell growth factor [TCGF(IL2)] by T cells. 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| identifier | ISSN: 0022-1007 |
| ispartof | The Journal of experimental medicine, 1980-06, Vol.151 (6), p.1551-1556 |
| issn | 0022-1007 1540-9538 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Antigens Cell Adhesion Cell Communication Glucocorticoids - pharmacology Growth Substances - physiology Interleukin-1 Interleukin-2 - physiology Lectins Lymphocyte Activation - drug effects Lymphokines - physiology Macrophages - immunology Mice Mice, Nude - immunology Monocytes - immunology Proteins - physiology T-Lymphocytes - immunology |
| title | The functional relationship of the interleukins |
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