Chédiak-Higashi gene in humans I. Impairment of natural-killer function

Natural-killer (NK)-cell function was profoundly depressed in donors homozygous for the Chediak-Steinbrinck-Higashi syndrome (C-HS) gene when compared with age- and sex-matched normals. This apparent defect was not simply a result of a delayed response because little cytolysis was evident in kinetic...

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Veröffentlicht in:	The Journal of experimental medicine 1980-05, Vol.151 (5), p.1039-1048
Hauptverfasser:	Haliotis, T, Roder, J, Klein, M, Ortaldo, J, Fauci, A S, Herberman, R B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Cells, Cultured Chediak-Higashi Syndrome - immunology Humans Immunity, Cellular Immunity, Innate - drug effects Interferons - pharmacology Killer Cells, Natural - immunology Lymphocytes - immunology Male T-Lymphocytes, Regulatory - immunology
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