Peroxidase-mediated mammalian cell cytotoxicity

Lactoperoxidase, in the presence of hydrogen peroxide and iodide is cytotoxic for human and mouse lymphoid cells, and human erythrocytes. Myeloperoxidase, in amounts equivalent to 1.5 x 10(6) neutrophils, readily replaces lactoperoxidase, and allows the substitution of the iodide ion by chloride. Th...

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Veröffentlicht in:	The Journal of experimental medicine 1973-07, Vol.138 (1), p.318-323
Hauptverfasser:	Edelson, P J, Cohn, Z A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brief Definitive Reports Cells, Cultured Chromium Isotopes Cytotoxicity Tests, Immunologic Erythrocytes - drug effects Erythrocytes - immunology Glucose Oxidase - pharmacology Iodides - pharmacology Isotope Labeling Leukemia L1210 Leukocytes - drug effects Leukocytes - immunology Methods Mice Peroxidases - pharmacology Trypan Blue
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