Variable Prostaglandin E2 Resistance in Fibroblasts from Patients with Usual Interstitial Pneumonia

Prostaglandin (PG) E2, a cyclooxygenase-derived lipid mediator, is a potent down-regulator of fibroblast activation in normal lung fibroblasts. Although fibroblasts from patients with idiopathic pulmonary fibrosis are known to exhibit a defect in PGE2 synthesis, there is little information about the...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2008-01, Vol.177 (1), p.66-74
Hauptverfasser:	Huang, Steven K, Wettlaufer, Scott H, Hogaboam, Cory M, Flaherty, Kevin R, Martinez, Fernando J, Myers, Jeffrey L, Colby, Thomas V, Travis, William D, Toews, Galen B, Peters-Golden, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Cell Division - drug effects Cell Line Clinical death. Palliative care. Organ gift and preservation Collagen Type I - metabolism Cyclic AMP - metabolism Dinoprostone - pharmacology Drug Resistance E. Interstitial Lung Disease Female Fibroblasts - drug effects Fibroblasts - pathology Humans Intensive care medicine Lung - pathology Lung Diseases, Interstitial - pathology Male Medical sciences Middle Aged Pharmacology. Drug treatments Pulmonary Fibrosis - pathology
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