Comparison of the cardiovascular and neural activity of endothelin‐1, −2, −3 and respective proendothelins: effects of phosphoramidon and thiorphan

1 In the anaesthetized, ganglion‐blocked rat, intravenous boluses of endothelin‐1, endothelin‐2 and endothelin‐3 induced a transient hypotensive effect followed by a potent long lasting pressor response (ED50 mmHg: 0.72 ± 0.05, 1.8 ± 0.2 and 2.7 ± 0.3 nmol kg−1, respectively). The maximal effect for...

Ausführliche Beschreibung