Heme oxygenase-1 induction by NRF2 requires inactivation of the transcriptional repressor BACH1

Oxidative stress activates the transcription factor NRF2, which in turn binds cis-acting antioxidant response element (ARE) enhancers and induces expression of protective antioxidant genes. In contrast, the transcriptional repressor BACH1 binds ARE-like enhancers in cells naïve to oxidative stress a...

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Veröffentlicht in:	Nucleic acids research 2007-12, Vol.35 (21), p.7074-7086
Hauptverfasser:	Reichard, John F, Motz, Gregory T, Puga, Alvaro
Format:	Artikel
Sprache:	eng
Schlagworte:	Basic-Leucine Zipper Transcription Factors - antagonists & inhibitors Basic-Leucine Zipper Transcription Factors - metabolism Binding Sites Cell Line Enhancer Elements, Genetic Fanconi Anemia Complementation Group Proteins - antagonists & inhibitors Fanconi Anemia Complementation Group Proteins - metabolism Heme Oxygenase-1 - biosynthesis Heme Oxygenase-1 - genetics Humans Molecular Biology NF-E2-Related Factor 2 - metabolism Oxidative Stress Promoter Regions, Genetic Repressor Proteins - antagonists & inhibitors Repressor Proteins - metabolism Response Elements Transcriptional Activation
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