Role of p120 Ras-GAP in Directed Cell Movement

We have used cell lines deficient in p120 Ras GTPase activating protein (Ras-GAP) to investigate the roles of Ras-GAP and the associated p190 Rho-GAP (p190) in cell polarity and cell migration. Cell wounding assays showed that Ras-GAP-deficient cells were incapable of establishing complete cell pola...

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Veröffentlicht in:	The Journal of cell biology 2000-04, Vol.149 (2), p.457-470
Hauptverfasser:	Kulkarni, Sarang V., Gish, Gerald, van der Geer, Peter, Henkemeyer, Mark, Pawson, Tony
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins Animals Antibodies B lymphocytes Cell growth Cell lines Cell motility Cell Movement - physiology Cell Polarity - physiology Cells Cells, Cultured Cellular biology Cytoskeleton - physiology Cytoskeleton - ultrastructure DNA-Binding Proteins Embryo, Mammalian - cytology Endothelial cells Golgi Apparatus - physiology Golgi Apparatus - ultrastructure GTPase-Activating Proteins Guanine Nucleotide Exchange Factors Injuries Mice Mice, Knockout Microinjections Microtubules - physiology Microtubules - ultrastructure Nuclear Proteins - chemistry Nuclear Proteins - metabolism Original p120 GTPase Activating Protein - deficiency p120 GTPase Activating Protein - genetics p120 GTPase Activating Protein - metabolism Peptide Fragments - chemistry Peptide Fragments - pharmacology Phosphoproteins - chemistry Phosphoproteins - metabolism Proteins ras-GRF1 Recombinant Proteins - metabolism Repressor Proteins Swiss 3T3 cells Transfection Yolk Sac - cytology
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