Tumor Necrosis Factor Induces Hyperphosphorylation of Kinesin Light Chain and Inhibits Kinesin-Mediated Transport of Mitochondria

The molecular motor kinesin is an ATPase that mediates plus end-directed transport of organelles along microtubules. Although the biochemical properties of kinesin are extensively studied, conclusive data on regulation of kinesin-mediated transport are largely lacking. Previously, we showed that the...

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Veröffentlicht in:	The Journal of cell biology 2000-06, Vol.149 (6), p.1207-1214
Hauptverfasser:	de Vos, Kurt, Severin, Fedor, van Herreweghe, Franky, Vancompernolle, Katia, Goossens, Vera, Hyman, Anthony, Grooten, Johan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell culture techniques Cell Line Cells Cellular biology Cytosol Enzyme Activation Enzyme Inhibitors - pharmacology Gliding Imidazoles - pharmacology Kinesin - metabolism Light Microtubule-Associated Proteins - metabolism Microtubules Microtubules - metabolism Mitochondria Mitochondria - metabolism Mitogen-Activated Protein Kinases - metabolism Molecular Motor Proteins - metabolism Organelles Original p38 Mitogen-Activated Protein Kinases Phosphorylation Protein isoforms Proteins Pyridines - pharmacology Receptors, Tumor Necrosis Factor - metabolism Signal Transduction Tumor Necrosis Factor-alpha - pharmacology Tumor necrosis factors Tumors
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