The Role of Intraorganellar Ca2+in Late Endosome-Lysosome Heterotypic Fusion and in the Reformation of Lysosomes from Hybrid Organelles

We have investigated the requirement for Ca2+in the fusion and content mixing of rat hepatocyte late endosomes and lysosomes in a cell-free system. Fusion to form hybrid organelles was inhibited by 1,2-bis(2-aminophenoxy) ethane-N,N,N′,N′-tetraacetic acid (BAPTA), but not by EGTA, and this inhibitio...

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Veröffentlicht in:	The Journal of cell biology 2000-05, Vol.149 (5), p.1053-1062
Hauptverfasser:	Pryor, Paul R., Mullock, Barbara M., Bright, Nicholas A., Gray, Sally R., Luzio, J. Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium Cellular biology Centrifugation Endosomes Epithelial cells Guanine nucleotide dissociation inhibitors Hepatocytes Liver Lysosomes Membranes Organelles Original Vacuoles Yeasts
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