Gemin4: A Novel Component of the SMN Complex That Is Found in Both Gems and Nucleoli

The survival of motor neurons (SMN) protein, the product of the neurodegenerative disease spinal muscular atrophy (SMA) gene, is localized both in the cytoplasm and in discrete nuclear bodies called gems. In both compartments SMN is part of a large complex that contains several proteins including Ge...

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Veröffentlicht in:	The Journal of cell biology 2000-03, Vol.148 (6), p.1177-1186
Hauptverfasser:	Charroux, Bernard, Pellizzoni, Livio, Perkinson, Robert A., Yong, Jeongsik, Shevchenko, Andrej, Mann, Matthias, Dreyfuss, Gideon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Monoclonal Cell nucleolus Cell Nucleolus - physiology Cell Nucleolus - ultrastructure Cell Nucleus - physiology Cell Nucleus - ultrastructure Cellular biology Cyclic AMP Response Element-Binding Protein Cytoplasm Cytoplasm - physiology Cytoplasm - ultrastructure DEAD Box Protein 20 DEAD-box RNA Helicases Female HeLa Cells Humans Immunoprecipitation Minor Histocompatibility Antigens Models, Molecular Muscular Atrophy, Spinal - genetics Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurological disorders Nuclear Proteins - analysis Nuclear Proteins - genetics Nuclear Proteins - metabolism Oocytes Oocytes - physiology Oocytes - ultrastructure Original Proteins Ribonucleic acid Ribonucleoproteins, Small Nuclear - metabolism RNA RNA Helicases - analysis RNA Helicases - metabolism RNA-Binding Proteins Small nuclear ribonucleoproteins Small nuclear RNA SMN Complex Proteins Spinal muscular atrophy Xenopus laevis
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