Serum Response Factor Is Crucial for Actin Cytoskeletal Organization and Focal Adhesion Assembly in Embryonic Stem Cells

The activity of serum response factor (SRF), an essential transcription factor in mouse gastrulation, is regulated by changes in actin dynamics. Using Srf(-/-) embryonic stem (ES) cells, we demonstrate that SRF deficiency causes impairments in ES cell spreading, adhesion, and migration. These defect...

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Veröffentlicht in:	The Journal of cell biology 2002-02, Vol.156 (4), p.737-750
Hauptverfasser:	Schratt, Gerhard, Philippar, Ulrike, Berger, Jürgen, Schwarz, Heinz, Heidenreich, Olaf, Nordheim, Alfred
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins Actins - genetics Actins - metabolism Animals Antibodies Cell adhesion Cell Adhesion - physiology Cell lines Cell Movement - physiology Cells Cellular biology Cytoskeleton - metabolism Cytoskeleton - physiology Embryos Enzyme Activation focal adhesion kinase Focal Adhesion Kinase 1 Focal Adhesion Protein-Tyrosine Kinases Focal adhesions Focal Adhesions - physiology Gene Expression Regulation Genes Herpes Simplex Virus Protein Vmw65 - genetics Herpes Simplex Virus Protein Vmw65 - metabolism Integrin beta1 - genetics Integrin beta1 - metabolism Membranes Metalloproteins - genetics Metalloproteins - metabolism Mice Mice, Knockout Protein-Tyrosine Kinases - metabolism Proteins Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism rhoA GTP-Binding Protein - metabolism Rodents serum response factor Serum Response Factor - genetics Serum Response Factor - physiology Stem cells Stem Cells - cytology Stress fibers talin Talin - genetics Talin - metabolism vinculin Vinculin - genetics Vinculin - metabolism Zyxin
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