Loss of Proteolytically Processed Filaggrin Caused by Epidermal Deletion of Matriptase/MT-SP1

Profilaggrin is a large epidermal polyprotein that is proteolytically processed during keratinocyte differentiation to release multiple filaggrin monomer, units as well as a calcium-binding regulatory NH2-terminal filaggrin S-100 protein. We show that epidermal deficiency of the transmembrane serine...

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Veröffentlicht in:	The Journal of cell biology 2003-11, Vol.163 (4), p.901-910
Hauptverfasser:	List, Karin, Szabo, Roman, Wertz, Philip W., Segre, Julie, Haudenschild, Christian C., Kim, Soo-Youl, Bugge, Thomas H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Cell Differentiation - genetics Cellular biology Dehydration - enzymology Epidermis Epidermis - enzymology Epidermis - growth & development Epidermis - pathology Extracellular Matrix - genetics Extracellular Matrix - metabolism Extracellular Matrix - pathology filaggrin Ichthyosis Ichthyosis - enzymology Ichthyosis - genetics Ichthyosis - pathology Intermediate Filament Proteins - biosynthesis Intermediate Filament Proteins - deficiency Intermediate Filament Proteins - metabolism Keratinocytes Keratinocytes - enzymology Keratinocytes - pathology Keratinocytes - ultrastructure Lipid Metabolism Lipids Matriptase Membrane Proteins Mice Mice, Knockout Microscopy, Electron Monomers MT-SP1 protein Newborns Peptide Hydrolases - deficiency Peptide Hydrolases - genetics Permeability Protein Precursors - metabolism Proteins S100 Proteins - metabolism Serine Endopeptidases - deficiency Serine Endopeptidases - genetics Skin Skin Abnormalities - enzymology Skin Abnormalities - genetics Skin Abnormalities - pathology Skin diseases Trypsin - deficiency Trypsin - genetics
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