p38 MAP Kinase Negatively Regulates Endothelial Cell Survival, Proliferation, and Differentiation in FGF-2-Stimulated Angiogenesis

The p38 mitogen-activated protein kinase (p38) is activated in response to environmental stress and inflammatory cytokines. Although several growth factors, including fibroblast growth factor (FGF)-2, mediate activation of p38, the consequences for growth factor-dependent cellular functions have not...

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Veröffentlicht in:	The Journal of cell biology 2002-01, Vol.156 (1), p.149-160
Hauptverfasser:	Matsumoto, Taro, Turesson, Ingela, Book, Majlis, Gerwins, Pär, Claesson-Welsh, Lena
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Apoptosis Apoptosis - drug effects Blood vessels Calcium-Binding Proteins Capillaries - cytology Capillaries - drug effects Capillaries - growth & development Cattle Cell culture techniques Cell Differentiation - drug effects Cell Division - drug effects Cell growth Cell lines Cell Survival - drug effects Cellular biology Chick Embryo Collagens Cultured cells Cytokines DNA - biosynthesis Endothelial cells Endothelial Growth Factors - pharmacology Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - enzymology Endothelium, Vascular - growth & development Enzyme Activation - drug effects Enzymes Fibroblast Growth Factor 2 - antagonists & inhibitors Fibroblast Growth Factor 2 - pharmacology Gels Imidazoles - pharmacology Intercellular Signaling Peptides and Proteins Lymphokines - pharmacology Membrane Proteins Mitogen-Activated Protein Kinase Kinases - genetics Mitogen-Activated Protein Kinase Kinases - metabolism Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism Morphogenesis Morphogenesis - drug effects Mutation Neovascularization, Physiologic - drug effects p38 Mitogen-Activated Protein Kinases Proteins - metabolism Pyridines - pharmacology Serrate-Jagged Proteins Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors
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