Force measurements in E-cadherin-mediated cell doublets reveal rapid adhesion strengthened by actin cytoskeleton remodeling through Rac and Cdc42

We have used a modified, dual pipette assay to quantify the strength of cadherin-dependent cell-cell adhesion. The force required to separate E-cadherin-expressing paired cells in suspension was measured as an index of intercellular adhesion. Separation force depended on the homophilic interaction o...

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Veröffentlicht in:	The Journal of cell biology 2004-12, Vol.167 (6), p.1183-1194
Hauptverfasser:	Chu, Yeh-Shiu, Thomas, William A, Eder, Olivier, Pincet, Frederic, Perez, Eric, Thiery, Jean Paul, Dufour, Sylvie
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins Actins - drug effects Actins - physiology Animals Antibodies Bridged Bicyclo Compounds, Heterocyclic - pharmacology Cadherins Cadherins - physiology cdc42 GTP-Binding Protein - physiology Cell adhesion Cell adhesion & migration Cell Adhesion - physiology Cell aggregates Cell Line Cell lines Cell Separation - methods Cellular biology Cytoskeleton - physiology Depsipeptides - pharmacology Embryonic cells Epithelial cells Gene expression Life Sciences Mice Microfilaments Pipettes rac GTP-Binding Proteins - physiology Thiazoles - pharmacology Thiazolidines Time Factors
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