Roles of p-ERM and Rho-ROCK Signaling in Lymphocyte Polarity and Uropod Formation

Front-rear asymmetry in motile cells is crucial for efficient directional movement. The uropod in migrating lymphocytes is a posterior protrusion in which several proteins, including CD44 and ezrin/radixin/moesin (ERM), are concentrated. In EL4.G8 T-lymphoma cells, Thr567 phosphorylation in the COOH...

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Veröffentlicht in:	The Journal of cell biology 2004-10, Vol.167 (2), p.327-337
Hauptverfasser:	Lee, Jong-Hwan, Katakai, Tomoya, Hara, Takahiro, Gonda, Hiroyuki, Sugai, Manabu, Shimizu, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins Actins - metabolism Amides - pharmacology Animals Blood Proteins - metabolism Blotting, Western Cell adhesion & migration Cell Line, Tumor Cell lines Cell Membrane - metabolism Cell membranes Cell Movement Cell Nucleus - metabolism Cells Cellular biology Chemotaxis Cytoplasm Cytoplasm - metabolism Cytoskeletal Proteins - metabolism Cytoskeleton Cytoskeleton - metabolism Enzyme Activation Enzyme Inhibitors - pharmacology Enzymes Green Fluorescent Proteins - metabolism Guanine Nucleotide Exchange Factors - metabolism Hyaluronan Receptors - biosynthesis Hyaluronan Receptors - metabolism Immunoprecipitation Intracellular Signaling Peptides and Proteins Lymphocytes Lymphocytes - metabolism Lymphoma, T-Cell - metabolism Membrane Proteins - metabolism Membranes Mice Microfilament Proteins - metabolism Microscopy, Fluorescence Models, Biological Phosphoproteins - metabolism Phosphorylation Plasma Plasmids - metabolism Polar caps Protein Structure, Tertiary Protein-Serine-Threonine Kinases - metabolism Proteins Pyridines - pharmacology rho-Associated Kinases rhoA GTP-Binding Protein - metabolism Schwann cells Signal Transduction T lymphocytes Time Factors Transfection
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