Apoptotic Pathways Are Selectively Activated by Granzyme A and/or Granzyme B in CTL-Mediated Target Cell Lysis

Purified cytolytic T lymphocyte (CTL) proteases granzyme (gzm)A and gzmB with sublytic dose of perforin (perf) initiate distinct proapoptotic pathways. Their physiological relevance in CTL-mediated target cell apoptosis is elusive. Using ex vivo virus-immune CD8+T cells from mice deficient in perf,...

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Veröffentlicht in:	The Journal of cell biology 2004-11, Vol.167 (3), p.457-468
Hauptverfasser:	Pardo, Julián, Bosque, Alberto, Brehm, Reina, Wallich, Reinhard, Naval, Javier, Müllbacher, Arno, Anel, Alberto, Simon, Markus M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - immunology Cell death Cell Line, Tumor Cell lines Cell membranes Cells Cells, Cultured Cellular biology Cultured cells Cytolysis Cytotoxicity, Immunologic Granzymes Kinetics Membrane Glycoproteins - physiology Membrane Potentials Mice Mice, Knockout Pathogens Perforin Phosphatidylserines - metabolism Pore Forming Cytotoxic Proteins Reactive Oxygen Species - metabolism Serine Endopeptidases - deficiency Serine Endopeptidases - physiology T lymphocytes T-Lymphocytes, Cytotoxic - enzymology T-Lymphocytes, Cytotoxic - immunology Time Factors Tumors Viruses
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