Oligodendroglial Modulation of Fast Axonal Transport in a Mouse Model of Hereditary Spastic Paraplegia
Oligodendrocytes are critical for the development of the plasma membrane and cytoskeleton of the axon. In this paper, we show that fast axonal transport is also dependent on the oligodendrocyte. Using a mouse model of hereditary spastic paraplegia type 2 due to a null mutation of the myelin Plp gene...
Gespeichert in:
| Veröffentlicht in: | The Journal of cell biology 2004-07, Vol.166 (1), p.121-131 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 131 |
|---|---|
| container_issue | 1 |
| container_start_page | 121 |
| container_title | The Journal of cell biology |
| container_volume | 166 |
| creator | Edgar, Julia M. McLaughlin, Mark Yool, Donald Zhang, Su-Chun Fowler, Jill H. Montague, Paul Barrie, Jennifer A. McCulloch, Mailis C. Duncan, Ian D. Garbern, James Nave, Klaus A. Griffiths, Ian R. |
| description | Oligodendrocytes are critical for the development of the plasma membrane and cytoskeleton of the axon. In this paper, we show that fast axonal transport is also dependent on the oligodendrocyte. Using a mouse model of hereditary spastic paraplegia type 2 due to a null mutation of the myelin Plp gene, we find a progressive impairment in fast retrograde and anterograde transport. Increased levels of retrograde motor protein subunits are associated with accumulation of membranous organelles distal to nodal complexes. Using cell transplantation, we show categorically that the axonal phenotype is related to the presence of the overlying Plp null myelin. Our data demonstrate a novel role for oligodendrocytes in the local regulation of axonal function and have implications for the axonal loss associated with secondary progressive multiple sclerosis. |
| doi_str_mv | 10.1083/jcb.200312012 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2172145</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>1622225</jstor_id><sourcerecordid>1622225</sourcerecordid><originalsourceid>FETCH-LOGICAL-c528t-ab24a9f5fef3ac224f7d7319ad29f954ed91d48819c7280394bd67ee28848ecb3</originalsourceid><addsrcrecordid>eNqF0c1rFDEYB-AgFrtWj95EBg_eps33x0UoxVqhpYL1HDL5WLNkJ2MyU_S_N8surfZiLjm8T968yQ-ANwieIijJ2cYOpxhCgjBE-BlYIUZhLxGFz8EKQox6xTA7Bi9r3UAIqaDkBThGDGNOoFiBcJviOjs_upLXKZrU3WS3JDPHPHY5dJemzt35rzy2yl0xY51ymbs4dqbBpfod92knr3zxLs6m_O6-Te1UtN1XU8yU_DqaV-AomFT968N-Ar5ffrq7uOqvbz9_uTi_7i3Dcu7NgKlRgQUfiLEY0yCcIEgZh1VQjHqnkKNSImUFlpAoOjguvMdSUuntQE7Ax33faRm23lk_zsUkPZW4bYPpbKL-tzLGH3qd7zVGAiPKWoMPhwYl_1x8nfU2VutTMqNv79Wcc8mpUv-FSEgmlOINvn8CN3kp7T_r7lIouUK4oX6PbMm1Fh8eRkZQ73LWLWf9kHPz7_5-56M-BNvA2z3Y1DmXxzrHbTHyB7Xcre4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>217086912</pqid></control><display><type>article</type><title>Oligodendroglial Modulation of Fast Axonal Transport in a Mouse Model of Hereditary Spastic Paraplegia</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Edgar, Julia M. ; McLaughlin, Mark ; Yool, Donald ; Zhang, Su-Chun ; Fowler, Jill H. ; Montague, Paul ; Barrie, Jennifer A. ; McCulloch, Mailis C. ; Duncan, Ian D. ; Garbern, James ; Nave, Klaus A. ; Griffiths, Ian R.</creator><creatorcontrib>Edgar, Julia M. ; McLaughlin, Mark ; Yool, Donald ; Zhang, Su-Chun ; Fowler, Jill H. ; Montague, Paul ; Barrie, Jennifer A. ; McCulloch, Mailis C. ; Duncan, Ian D. ; Garbern, James ; Nave, Klaus A. ; Griffiths, Ian R.</creatorcontrib><description>Oligodendrocytes are critical for the development of the plasma membrane and cytoskeleton of the axon. In this paper, we show that fast axonal transport is also dependent on the oligodendrocyte. Using a mouse model of hereditary spastic paraplegia type 2 due to a null mutation of the myelin Plp gene, we find a progressive impairment in fast retrograde and anterograde transport. Increased levels of retrograde motor protein subunits are associated with accumulation of membranous organelles distal to nodal complexes. Using cell transplantation, we show categorically that the axonal phenotype is related to the presence of the overlying Plp null myelin. Our data demonstrate a novel role for oligodendrocytes in the local regulation of axonal function and have implications for the axonal loss associated with secondary progressive multiple sclerosis.</description><identifier>ISSN: 0021-9525</identifier><identifier>EISSN: 1540-8140</identifier><identifier>DOI: 10.1083/jcb.200312012</identifier><identifier>PMID: 15226307</identifier><identifier>CODEN: JCLBA3</identifier><language>eng</language><publisher>United States: Rockefeller University Press</publisher><subject>Alleles ; Animals ; Axons ; Axons - metabolism ; Biological Transport ; Blotting, Western ; Cell Membrane - metabolism ; Cellular biology ; Cytoskeleton - metabolism ; Disease Models, Animal ; Heredity ; Heterozygote ; Immunohistochemistry ; Mice ; Mice, Mutant Strains ; Myelin ; Myelin Sheath - metabolism ; Nerves ; Neurons ; Oligodendroglia ; Oligodendroglia - metabolism ; Optic nerve ; Optic Nerve - metabolism ; Optics ; Organelles ; Paralysis ; Phenotype ; Reverse Transcriptase Polymerase Chain Reaction ; Rodents ; Spastic Paraplegia, Hereditary - genetics ; Spastic Paraplegia, Hereditary - metabolism ; Spastic Paraplegia, Hereditary - pathology ; Spinal cord ; Spinal Cord - pathology ; Time Factors</subject><ispartof>The Journal of cell biology, 2004-07, Vol.166 (1), p.121-131</ispartof><rights>Copyright 2004 The Rockefeller University Press</rights><rights>Copyright Rockefeller University Press Jul 5, 2004</rights><rights>Copyright © 2004, The Rockefeller University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c528t-ab24a9f5fef3ac224f7d7319ad29f954ed91d48819c7280394bd67ee28848ecb3</citedby><cites>FETCH-LOGICAL-c528t-ab24a9f5fef3ac224f7d7319ad29f954ed91d48819c7280394bd67ee28848ecb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15226307$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Edgar, Julia M.</creatorcontrib><creatorcontrib>McLaughlin, Mark</creatorcontrib><creatorcontrib>Yool, Donald</creatorcontrib><creatorcontrib>Zhang, Su-Chun</creatorcontrib><creatorcontrib>Fowler, Jill H.</creatorcontrib><creatorcontrib>Montague, Paul</creatorcontrib><creatorcontrib>Barrie, Jennifer A.</creatorcontrib><creatorcontrib>McCulloch, Mailis C.</creatorcontrib><creatorcontrib>Duncan, Ian D.</creatorcontrib><creatorcontrib>Garbern, James</creatorcontrib><creatorcontrib>Nave, Klaus A.</creatorcontrib><creatorcontrib>Griffiths, Ian R.</creatorcontrib><title>Oligodendroglial Modulation of Fast Axonal Transport in a Mouse Model of Hereditary Spastic Paraplegia</title><title>The Journal of cell biology</title><addtitle>J Cell Biol</addtitle><description>Oligodendrocytes are critical for the development of the plasma membrane and cytoskeleton of the axon. In this paper, we show that fast axonal transport is also dependent on the oligodendrocyte. Using a mouse model of hereditary spastic paraplegia type 2 due to a null mutation of the myelin Plp gene, we find a progressive impairment in fast retrograde and anterograde transport. Increased levels of retrograde motor protein subunits are associated with accumulation of membranous organelles distal to nodal complexes. Using cell transplantation, we show categorically that the axonal phenotype is related to the presence of the overlying Plp null myelin. Our data demonstrate a novel role for oligodendrocytes in the local regulation of axonal function and have implications for the axonal loss associated with secondary progressive multiple sclerosis.</description><subject>Alleles</subject><subject>Animals</subject><subject>Axons</subject><subject>Axons - metabolism</subject><subject>Biological Transport</subject><subject>Blotting, Western</subject><subject>Cell Membrane - metabolism</subject><subject>Cellular biology</subject><subject>Cytoskeleton - metabolism</subject><subject>Disease Models, Animal</subject><subject>Heredity</subject><subject>Heterozygote</subject><subject>Immunohistochemistry</subject><subject>Mice</subject><subject>Mice, Mutant Strains</subject><subject>Myelin</subject><subject>Myelin Sheath - metabolism</subject><subject>Nerves</subject><subject>Neurons</subject><subject>Oligodendroglia</subject><subject>Oligodendroglia - metabolism</subject><subject>Optic nerve</subject><subject>Optic Nerve - metabolism</subject><subject>Optics</subject><subject>Organelles</subject><subject>Paralysis</subject><subject>Phenotype</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Rodents</subject><subject>Spastic Paraplegia, Hereditary - genetics</subject><subject>Spastic Paraplegia, Hereditary - metabolism</subject><subject>Spastic Paraplegia, Hereditary - pathology</subject><subject>Spinal cord</subject><subject>Spinal Cord - pathology</subject><subject>Time Factors</subject><issn>0021-9525</issn><issn>1540-8140</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c1rFDEYB-AgFrtWj95EBg_eps33x0UoxVqhpYL1HDL5WLNkJ2MyU_S_N8surfZiLjm8T968yQ-ANwieIijJ2cYOpxhCgjBE-BlYIUZhLxGFz8EKQox6xTA7Bi9r3UAIqaDkBThGDGNOoFiBcJviOjs_upLXKZrU3WS3JDPHPHY5dJemzt35rzy2yl0xY51ymbs4dqbBpfod92knr3zxLs6m_O6-Te1UtN1XU8yU_DqaV-AomFT968N-Ar5ffrq7uOqvbz9_uTi_7i3Dcu7NgKlRgQUfiLEY0yCcIEgZh1VQjHqnkKNSImUFlpAoOjguvMdSUuntQE7Ax33faRm23lk_zsUkPZW4bYPpbKL-tzLGH3qd7zVGAiPKWoMPhwYl_1x8nfU2VutTMqNv79Wcc8mpUv-FSEgmlOINvn8CN3kp7T_r7lIouUK4oX6PbMm1Fh8eRkZQ73LWLWf9kHPz7_5-56M-BNvA2z3Y1DmXxzrHbTHyB7Xcre4</recordid><startdate>20040705</startdate><enddate>20040705</enddate><creator>Edgar, Julia M.</creator><creator>McLaughlin, Mark</creator><creator>Yool, Donald</creator><creator>Zhang, Su-Chun</creator><creator>Fowler, Jill H.</creator><creator>Montague, Paul</creator><creator>Barrie, Jennifer A.</creator><creator>McCulloch, Mailis C.</creator><creator>Duncan, Ian D.</creator><creator>Garbern, James</creator><creator>Nave, Klaus A.</creator><creator>Griffiths, Ian R.</creator><general>Rockefeller University Press</general><general>The Rockefeller University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20040705</creationdate><title>Oligodendroglial Modulation of Fast Axonal Transport in a Mouse Model of Hereditary Spastic Paraplegia</title><author>Edgar, Julia M. ; McLaughlin, Mark ; Yool, Donald ; Zhang, Su-Chun ; Fowler, Jill H. ; Montague, Paul ; Barrie, Jennifer A. ; McCulloch, Mailis C. ; Duncan, Ian D. ; Garbern, James ; Nave, Klaus A. ; Griffiths, Ian R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c528t-ab24a9f5fef3ac224f7d7319ad29f954ed91d48819c7280394bd67ee28848ecb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Alleles</topic><topic>Animals</topic><topic>Axons</topic><topic>Axons - metabolism</topic><topic>Biological Transport</topic><topic>Blotting, Western</topic><topic>Cell Membrane - metabolism</topic><topic>Cellular biology</topic><topic>Cytoskeleton - metabolism</topic><topic>Disease Models, Animal</topic><topic>Heredity</topic><topic>Heterozygote</topic><topic>Immunohistochemistry</topic><topic>Mice</topic><topic>Mice, Mutant Strains</topic><topic>Myelin</topic><topic>Myelin Sheath - metabolism</topic><topic>Nerves</topic><topic>Neurons</topic><topic>Oligodendroglia</topic><topic>Oligodendroglia - metabolism</topic><topic>Optic nerve</topic><topic>Optic Nerve - metabolism</topic><topic>Optics</topic><topic>Organelles</topic><topic>Paralysis</topic><topic>Phenotype</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Rodents</topic><topic>Spastic Paraplegia, Hereditary - genetics</topic><topic>Spastic Paraplegia, Hereditary - metabolism</topic><topic>Spastic Paraplegia, Hereditary - pathology</topic><topic>Spinal cord</topic><topic>Spinal Cord - pathology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Edgar, Julia M.</creatorcontrib><creatorcontrib>McLaughlin, Mark</creatorcontrib><creatorcontrib>Yool, Donald</creatorcontrib><creatorcontrib>Zhang, Su-Chun</creatorcontrib><creatorcontrib>Fowler, Jill H.</creatorcontrib><creatorcontrib>Montague, Paul</creatorcontrib><creatorcontrib>Barrie, Jennifer A.</creatorcontrib><creatorcontrib>McCulloch, Mailis C.</creatorcontrib><creatorcontrib>Duncan, Ian D.</creatorcontrib><creatorcontrib>Garbern, James</creatorcontrib><creatorcontrib>Nave, Klaus A.</creatorcontrib><creatorcontrib>Griffiths, Ian R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Edgar, Julia M.</au><au>McLaughlin, Mark</au><au>Yool, Donald</au><au>Zhang, Su-Chun</au><au>Fowler, Jill H.</au><au>Montague, Paul</au><au>Barrie, Jennifer A.</au><au>McCulloch, Mailis C.</au><au>Duncan, Ian D.</au><au>Garbern, James</au><au>Nave, Klaus A.</au><au>Griffiths, Ian R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oligodendroglial Modulation of Fast Axonal Transport in a Mouse Model of Hereditary Spastic Paraplegia</atitle><jtitle>The Journal of cell biology</jtitle><addtitle>J Cell Biol</addtitle><date>2004-07-05</date><risdate>2004</risdate><volume>166</volume><issue>1</issue><spage>121</spage><epage>131</epage><pages>121-131</pages><issn>0021-9525</issn><eissn>1540-8140</eissn><coden>JCLBA3</coden><abstract>Oligodendrocytes are critical for the development of the plasma membrane and cytoskeleton of the axon. In this paper, we show that fast axonal transport is also dependent on the oligodendrocyte. Using a mouse model of hereditary spastic paraplegia type 2 due to a null mutation of the myelin Plp gene, we find a progressive impairment in fast retrograde and anterograde transport. Increased levels of retrograde motor protein subunits are associated with accumulation of membranous organelles distal to nodal complexes. Using cell transplantation, we show categorically that the axonal phenotype is related to the presence of the overlying Plp null myelin. Our data demonstrate a novel role for oligodendrocytes in the local regulation of axonal function and have implications for the axonal loss associated with secondary progressive multiple sclerosis.</abstract><cop>United States</cop><pub>Rockefeller University Press</pub><pmid>15226307</pmid><doi>10.1083/jcb.200312012</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-9525 |
| ispartof | The Journal of cell biology, 2004-07, Vol.166 (1), p.121-131 |
| issn | 0021-9525 1540-8140 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2172145 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Alleles Animals Axons Axons - metabolism Biological Transport Blotting, Western Cell Membrane - metabolism Cellular biology Cytoskeleton - metabolism Disease Models, Animal Heredity Heterozygote Immunohistochemistry Mice Mice, Mutant Strains Myelin Myelin Sheath - metabolism Nerves Neurons Oligodendroglia Oligodendroglia - metabolism Optic nerve Optic Nerve - metabolism Optics Organelles Paralysis Phenotype Reverse Transcriptase Polymerase Chain Reaction Rodents Spastic Paraplegia, Hereditary - genetics Spastic Paraplegia, Hereditary - metabolism Spastic Paraplegia, Hereditary - pathology Spinal cord Spinal Cord - pathology Time Factors |
| title | Oligodendroglial Modulation of Fast Axonal Transport in a Mouse Model of Hereditary Spastic Paraplegia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T15%3A02%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Oligodendroglial%20Modulation%20of%20Fast%20Axonal%20Transport%20in%20a%20Mouse%20Model%20of%20Hereditary%20Spastic%20Paraplegia&rft.jtitle=The%20Journal%20of%20cell%20biology&rft.au=Edgar,%20Julia%20M.&rft.date=2004-07-05&rft.volume=166&rft.issue=1&rft.spage=121&rft.epage=131&rft.pages=121-131&rft.issn=0021-9525&rft.eissn=1540-8140&rft.coden=JCLBA3&rft_id=info:doi/10.1083/jcb.200312012&rft_dat=%3Cjstor_pubme%3E1622225%3C/jstor_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=217086912&rft_id=info:pmid/15226307&rft_jstor_id=1622225&rfr_iscdi=true |