ZIP Kinase Is Responsible for the Phosphorylation of Myosin II and Necessary for Cell Motility in Mammalian Fibroblasts

Reorganization of actomyosin is an essential process for cell migration and myosin regulatory light chain ( MLC20) phosphorylation plays a key role in this process. Here, we found that zipper-interacting protein (ZIP) kinase plays a predominant role in myosin II phosphorylation in mammalian fibrobla...

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Veröffentlicht in:	The Journal of cell biology 2004-04, Vol.165 (2), p.243-254
Hauptverfasser:	Komatsu, Satoshi, Ikebe, Mitsuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Phospho-Specific - metabolism Apoptosis Regulatory Proteins Calcium-Calmodulin-Dependent Protein Kinases Cell extracts Cell Line Cell Movement - physiology Cell Polarity Cells COS cells Cultured cells Death-Associated Protein Kinases Enzyme Inhibitors - metabolism Enzymes Fibroblasts Fibroblasts - cytology Fibroblasts - physiology Leucine Zippers Mammals Muscular system Myosin Light Chains - genetics Myosin Light Chains - metabolism Myosin Type II - metabolism Myosin-Light-Chain Kinase - antagonists & inhibitors Myosin-Light-Chain Kinase - metabolism NIH 3T3 cells Phosphorylation Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Ribonucleic acid RNA RNA Interference Small interfering RNA Smooth muscle Subcellular Fractions - chemistry Subcellular Fractions - metabolism
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