An AIF Orthologue Regulates Apoptosis in Yeast

Apoptosis-inducing factor (AIF), a key regulator of cell death, is essential for normal mammalian development and participates in pathological apoptosis. The proapoptotic nature of AIF and its mode of action are controversial. Here, we show that the yeast AIF homologue Ynr074cp controls yeast apopto...

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Veröffentlicht in:	The Journal of cell biology 2004-09, Vol.166 (7), p.969-974
Hauptverfasser:	Wissing, Silke, Ludovico, Paula, Herker, Eva, Büttner, Sabrina, Engelhardt, Silvia M., Decker, Thorsten, Link, Alexander, Proksch, Astrid, Rodrigues, Fernando, Corte-Real, Manuela, Fröhlich, Kai-Uwe, Manns, Joachim, Candé, Céline, Sigrist, Stephan J., Kroemer, Guido, Madeo, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Apoptosis Apoptosis - genetics Apoptosis Inducing Factor Caspase Inhibitors Caspases - metabolism Cell cycle Cell death Cell nucleus Cell Nucleus - genetics Cell Nucleus - metabolism Cells Cells, Cultured Cellular biology Cellular Senescence - genetics cyclophilin A Cyclophilin A - antagonists & inhibitors Cyclophilin A - metabolism Directional control DNA DNA - genetics DNA - metabolism DNA, Complementary - analysis DNA, Complementary - genetics Enzyme Inhibitors - pharmacology Flavoproteins - genetics Flavoproteins - isolation & purification Flavoproteins - metabolism Hydrogen Peroxide - pharmacology Mammals Membrane Proteins - genetics Membrane Proteins - isolation & purification Membrane Proteins - metabolism Mitochondria Mitochondria - genetics Mitochondria - metabolism Molecular Sequence Data Mother cells NADH, NADPH Oxidoreductases - genetics NADH, NADPH Oxidoreductases - isolation & purification NADH, NADPH Oxidoreductases - metabolism Oxidative Stress - genetics Plasmids Protein Transport - genetics Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - antagonists & inhibitors Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - isolation & purification Saccharomyces cerevisiae Proteins - metabolism Science & Technology Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid YCA1 Yeast Yeasts YNR074C
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