Integrins control motile strategy through a Rho-cofilin pathway

During wound healing, angiogenesis, and tumor invasion, cells often change their expression profiles of fibronectin-binding integrins. Here, we show that {szligbeta}1 integrins promote random migration, whereas {szligbeta}3 integrins promote persistent migration in the same epithelial cell backgroun...

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Veröffentlicht in:	The Journal of cell biology 2005-05, Vol.169 (3), p.515-526
Hauptverfasser:	Danen, Erik H.J, van Rheenen, Jacco, Franken, Willeke, Huveneers, Stephan, Sonneveld, Petra, Jalink, Kees, Sonnenberg, Arnoud
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton - metabolism Actin Depolymerizing Factors Actins Animals Cell adhesion Cell adhesion & migration Cell Adhesion - physiology Cell Line Cell matrix junctions Cell Membrane - metabolism Cell Movement - physiology Cell Polarity - physiology Cellular biology Cytoskeleton - metabolism Epithelial cells Fibronectins - metabolism Fluorescence Integrin beta1 - metabolism Integrin beta3 - metabolism Integrins Integrins - metabolism Mice Microfilament Proteins - metabolism Phosphorylation Physiological regulation Proteins Pseudopodia Pseudopodia - metabolism rho GTP-Binding Proteins - metabolism rhoA GTP-Binding Protein - metabolism Signal transduction Signal Transduction - physiology
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