Endoplasmic Reticulum Stress Modulates the Response of Myelinating Oligodendrocytes to the Immune Cytokine Interferon-γ

Interferon-γ (IFN-γ) is believed to contribute to immune-mediated demyelinating disorders by targeting the myelin-producing oligodendrocyte, a cell known to be highly sensitive to the disruption of protein synthesis and to the perturbation of the secretory pathway. We found that apoptosis induced by...

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Veröffentlicht in:	The Journal of cell biology 2005-05, Vol.169 (4), p.603-612
Hauptverfasser:	Lin, Wensheng, Harding, Heather P., Ron, David, Popko, Brian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Antisense elements Apoptosis Apoptosis - genetics Apoptosis - immunology Cells Cellular biology Central nervous system Cytokines Demyelinating Diseases - genetics Demyelinating Diseases - immunology Demyelinating Diseases - metabolism eIF-2 Kinase - genetics eIF-2 Kinase - metabolism Encephalitis - genetics Encephalitis - immunology Encephalitis - metabolism Endoplasmic reticulum Endoplasmic Reticulum - immunology Endoplasmic Reticulum - metabolism Eukaryotic Initiation Factor-2 - genetics Eukaryotic Initiation Factor-2 - immunology Eukaryotic Initiation Factor-2 - metabolism Female Homeostasis Immune system Interferon-gamma - genetics Interferon-gamma - immunology Interferon-gamma - metabolism Male Messenger RNA Mice Mice, Knockout Mice, Transgenic Microscopy, Electron, Transmission Mutation - genetics Myelin Myelin Sheath - metabolism Myelin Sheath - pathology Myelin Sheath - ultrastructure Oligodendroglia Oligodendroglia - immunology Oligodendroglia - metabolism Phosphorylation Rats Spinal cord Stress Stress, Physiological - genetics Stress, Physiological - immunology Stress, Physiological - metabolism Transgenic animals
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