Aurora A phosphorylation of TACC3/maskin is required for centrosome-dependent microtubule assembly in mitosis

Centrosomes act as sites of microtubule growth, but little is known about how the number and stability of microtubules emanating from a centrosome are controlled during the cell cycle. We studied the role of the TACC3-XMAP215 complex in this process by using purified proteins and Xenopus laevis egg...

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Veröffentlicht in:	The Journal of cell biology 2005-09, Vol.170 (7), p.1047-1055
Hauptverfasser:	Kinoshita, Kazuhisa, Noetzel, Tim L, Pelletier, Laurence, Mechtler, Karl, Drechsel, David N, Schwager, Anne, Lee, Mike, Raff, Jordan W, Hyman, Anthony A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Aurora Kinases Cell cycle Cell Cycle Proteins - physiology Cell Extracts Cells Cellular biology Centrosome - physiology Centrosomes Eggs Gene expression regulation Kinesin - metabolism Microtubule-Associated Proteins - metabolism Microtubule-Associated Proteins - physiology Microtubules Microtubules - chemistry Microtubules - metabolism Mitosis Mitotic spindle apparatus Oocytes - chemistry Phosphorylation Polymers Protein Kinases - physiology Protein-Serine-Threonine Kinases Proteins Transcription Factors - physiology Xenopus laevis Xenopus Proteins - metabolism Xenopus Proteins - physiology
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