Spines and neurite branches function as geometric attractors that enhance protein kinase C action

Ca²⁺ and diacylglycerol-regulated protein kinase Cs (PKCs; conventional PKC isoforms, such as PKC[gamma]) are multifunctional signaling molecules that undergo reversible plasma membrane translocation as part of their mechanism of activation. In this article, we investigate PKC[gamma] translocation i...

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Veröffentlicht in:	The Journal of cell biology 2005-09, Vol.170 (7), p.1147-1158
Hauptverfasser:	Craske, Madeleine L, Fivaz, Marc, Batada, Nizar N, Meyer, Tobias
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport Calcium Signaling Cell Membrane - chemistry Cell membranes Cells, Cultured Cellular biology Cytosol Cytosol - chemistry Dendrites Dendritic Spines - chemistry Dendritic Spines - enzymology Diffusion coefficient DNA - genetics Fluorescence Glutamic Acid - pharmacology Membrane Transport Proteins - analysis Membrane Transport Proteins - metabolism Membranes Microscopy, Confocal Models, Biological Neck Neurites - chemistry Neurites - enzymology Neurons Photobleaching Physiological regulation Protein Kinase C - analysis Protein Kinase C - genetics Protein Kinase C - metabolism Protein transport Proteins Rats Rats, Sprague-Dawley Signal transduction Signaling proteins Time Factors
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