ECT2-centralspindlin complex regulates the localization and function of RhoA

In anaphase, the spindle dictates the site of contractile ring assembly. Assembly and ingression of the contractile ring involves activation of myosin-II and actin polymerization, which are triggered by the GTPase RhoA. In many cells, the central spindle affects division plane positioning via unknow...

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Veröffentlicht in:	The Journal of cell biology 2005-08, Vol.170 (4), p.571-582
Hauptverfasser:	Yůce, Özlem, Piekny, Alisa, Glotzer, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins Actins - metabolism Anaphase Anaphase - drug effects Animal cells Antibodies Aurora Kinases Cell Cycle Proteins - metabolism Cell division Cytokinesis Cytokinesis - drug effects DNA Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Gene expression regulation HeLa Cells Humans Metaphase Metaphase - drug effects Microtubule-Associated Proteins - metabolism Models, Biological Molecular biology Multiprotein Complexes - metabolism Myosin Type II - metabolism Phenotype Phosphorylation Phosphorylation - drug effects Protein Binding - drug effects Protein Transport - drug effects Protein-Serine-Threonine Kinases - antagonists & inhibitors Proteins Proto-Oncogene Proteins - metabolism rhoA GTP-Binding Protein - metabolism Spindle Apparatus - drug effects Spindle Apparatus - enzymology
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