Reduced Apaf-1 levels in cardiomyocytes engage strict regulation of apoptosis by endogenous XIAP

Overexpression studies have identified X-linked inhibitor of apoptosis protein (XIAP) as a potent inhibitor of caspases. However, the exact function of endogenous XIAP in regulating mammalian apoptosis is less clear. Endogenous XIAP strictly regulates cytochrome c-dependent caspase activation in sym...

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Veröffentlicht in:	The Journal of cell biology 2005-12, Vol.171 (6), p.925-930
Hauptverfasser:	Potts, Malia B, Vaughn, Allyson E, McDonough, Holly, Patterson, Cam, Deshmukh, Mohanish
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Apoptotic Protease-Activating Factor 1 Caspases - metabolism Cells Cells, Cultured Cellular biology Cytochromes Cytochromes c - metabolism Cytochromes c - pharmacology Cytosol - metabolism Fibroblasts Gene expression HeLa cells Intracellular Signaling Peptides and Proteins - metabolism Mice Microinjections Microscopy, Fluorescence Myocardium Myocytes, Cardiac - drug effects Myocytes, Cardiac - enzymology Myocytes, Cardiac - metabolism Neurons Physiological regulation Proteins - metabolism Rats Time Factors Transfection Ungulates X-Linked Inhibitor of Apoptosis Protein - metabolism X-Linked Inhibitor of Apoptosis Protein - pharmacology
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