Mitogen-inducible gene 6 is an endogenous inhibitor of HGF/Met-induced cell migration and neurite growth

Hepatocyte growth factor (HGF)/Met signaling controls cell migration, growth and differentiation in several embryonic organs and is implicated in human cancer. The physiologic mechanisms that attenuate Met signaling are not well understood. Here we report a mechanism by which mitogen-inducible gene...

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Veröffentlicht in:	The Journal of cell biology 2005-10, Vol.171 (2), p.337-348
Hauptverfasser:	Pante, Guido, Thompson, Jane, Lamballe, Fabienne, Iwata, Tomoko, Ferby, Ingvar, Barr, Francis A, Davies, Alun M, Maina, Flavio, Klein, Růdiger
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Binding sites cdc42 GTP-Binding Protein - genetics cdc42 GTP-Binding Protein - metabolism Cell adhesion & migration Cell growth Cell Line Cell lines Cell migration inhibition tests Cell Movement - drug effects Cell Movement - physiology Cellular Biology Gene expression Gene Expression Regulation Hepatocyte Growth Factor - antagonists & inhibitors Hepatocyte Growth Factor - metabolism Hepatocyte Growth Factor - pharmacology Hepatocytes Intracellular Signaling Peptides and Proteins Life Sciences Mice Neurites Neurites - drug effects Neurites - metabolism Neurons Plasmids Protein Conformation rac GTP-Binding Proteins - genetics rac GTP-Binding Proteins - metabolism Receptors RNA, Messenger - genetics Signal Transduction - physiology Small interfering RNA Stromal cells
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