Effects of fetal exposure to isoflurane on postnatal memory and learning in rats

In a maternal fetal rat model, we investigated the behavioral and neurotoxic effects of fetal exposure to isoflurane. Pregnant rats at gestational day 21 were anesthetized with 1.3% isoflurane for 6 h. Apoptosis was quantified in the hippocampus and cortex at 2 and 18 h after exposure in the fetal b...

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Veröffentlicht in:	Neuropharmacology 2007-12, Vol.53 (8), p.942-950
Hauptverfasser:	Li, Yujuan, Liang, Ge, Wang, Shouping, Meng, Qingcheng, Wang, Qiujun, Wei, Huafeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Anesthetics Anesthetics, Inhalation - adverse effects Anesthetics, Inhalation - metabolism Animals Animals, Newborn Apoptosis Apoptosis - drug effects Behavior, Animal - drug effects Caspase 3 - metabolism Developing brain DNA Fragmentation - drug effects Embryo, Mammalian Female Fetus Hippocampus - pathology In Situ Nick-End Labeling Isoflurane - adverse effects Isoflurane - metabolism Learning Maze Learning - drug effects Memory Memory - drug effects Neurons - drug effects Pregnancy Prenatal Exposure Delayed Effects - pathology Prenatal Exposure Delayed Effects - physiopathology Rats Space Perception - drug effects Time Factors
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