Postural responses to changing task conditions in patients with cerebellar lesions
OBJECTIVE To investigate the role of the cerebellum in postural adaptation for changes to the stimulus type of support surface displacements (backward translations v“toes up” rotations). METHODS A group of 13 patients with chronic, isolated lesions of the cerebellum and 15 control subjects were test...
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| Veröffentlicht in: | Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1998-11, Vol.65 (5), p.734-742 |
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| container_title | Journal of neurology, neurosurgery and psychiatry |
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| creator | Mummel, P Timmann, D Krause, U W H Boering, D Thilmann, A F Diener, H C Horak, F B |
| description | OBJECTIVE To investigate the role of the cerebellum in postural adaptation for changes to the stimulus type of support surface displacements (backward translations v“toes up” rotations). METHODS A group of 13 patients with chronic, isolated lesions of the cerebellum and 15 control subjects were tested. Automatic postural responses of the medial gastrocnemius and anterior tibial muscles were recorded. The first paradigm consisted of 10 rotational perturbations followed by 10 backward translations of the platform, and 10 backward translations followed by 10 rotations. The second paradigm consisted of 18 rotations and two randomly interposed translational perturbations, and 18 translations with two rotations randomly interposed. RESULTS When the type of perturbation changed from an expected translation to an unexpected rotation and vice versa both control subjects and cerebellar patients showed an immediate and significant change in the response amplitude of the medial gastrocnemius and at the same time an immediate and significant change in the response amplitude of the anterior tibial muscles. Neither controls nor cerebellar patients showed effects of prediction in surface displacements of unexpected types of perturbation. Both controls and cerebellar patients showed no gradual increase in the gastrocnemius response in subsequent trials of surface translations following a block of 10 surface rotations and no gradual increase in the response amplitude of the anterior tibial muscle in subsequent trials of surface rotations following a block of 10 surface translations. CONCLUSIONS Despite postural hypermetria, the integrity of the cerebellum does not seem critical for adaptation of postural synergies to changing stimulus types of surface displacements. The present results support previous findings suggesting that the main role of the cerebellum in automatic postural responses may be gain control. |
| doi_str_mv | 10.1136/jnnp.65.5.734 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2170325</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70041967</sourcerecordid><originalsourceid>FETCH-LOGICAL-b510t-4e902b84417e4dc77284093331ed11ea0891136ca92beb083674481888e9832a3</originalsourceid><addsrcrecordid>eNqFkc-LEzEcxYO4rHX16FEIKOJlan5OMhdBBnUXyiq6ireQSdM23WkyJhl1_3sztAzqxVy-h_fh5T0eAE8wWmJM61d774dlzZd8KSi7BxaY1bKiFH27DxYIEVJRxNED8DClPZqebM7BeSMxaphcgE8fQ8pj1D2MNg3BJ5tgDtDstN86v4VZp1togl-77IoKnYeDzs76nOBPl3fQ2Gg72_c6wt6miXkEzja6T_bx6V6AL-_e3rSX1erD-6v2zarqOEa5YrZBpJOMYWHZ2ghBJEMNpRTbNcZWl6BTP6Mb0tkOSVoLxiSWUtpGUqLpBXh99B3G7mDXpmQqPdQQ3UHHOxW0U38r3u3UNvxQBAtECS8GL04GMXwfbcrq4JKZungbxqQEQgw3tSjgs3_AfRijL-UUFhJzjhtBClUdKRNDStFu5igYqamKmqZSNVdclakK__TP_DN92qboz0-6Tkb3m6i9cWnGCCMUlSLzty5l-2uWdbxVJbrg6vprq9obguTn65VqC__yyHeH_X8S_gaDBrjJ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1781551972</pqid></control><display><type>article</type><title>Postural responses to changing task conditions in patients with cerebellar lesions</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Mummel, P ; Timmann, D ; Krause, U W H ; Boering, D ; Thilmann, A F ; Diener, H C ; Horak, F B</creator><creatorcontrib>Mummel, P ; Timmann, D ; Krause, U W H ; Boering, D ; Thilmann, A F ; Diener, H C ; Horak, F B</creatorcontrib><description>OBJECTIVE To investigate the role of the cerebellum in postural adaptation for changes to the stimulus type of support surface displacements (backward translations v“toes up” rotations). METHODS A group of 13 patients with chronic, isolated lesions of the cerebellum and 15 control subjects were tested. Automatic postural responses of the medial gastrocnemius and anterior tibial muscles were recorded. The first paradigm consisted of 10 rotational perturbations followed by 10 backward translations of the platform, and 10 backward translations followed by 10 rotations. The second paradigm consisted of 18 rotations and two randomly interposed translational perturbations, and 18 translations with two rotations randomly interposed. RESULTS When the type of perturbation changed from an expected translation to an unexpected rotation and vice versa both control subjects and cerebellar patients showed an immediate and significant change in the response amplitude of the medial gastrocnemius and at the same time an immediate and significant change in the response amplitude of the anterior tibial muscles. Neither controls nor cerebellar patients showed effects of prediction in surface displacements of unexpected types of perturbation. Both controls and cerebellar patients showed no gradual increase in the gastrocnemius response in subsequent trials of surface translations following a block of 10 surface rotations and no gradual increase in the response amplitude of the anterior tibial muscle in subsequent trials of surface rotations following a block of 10 surface translations. CONCLUSIONS Despite postural hypermetria, the integrity of the cerebellum does not seem critical for adaptation of postural synergies to changing stimulus types of surface displacements. The present results support previous findings suggesting that the main role of the cerebellum in automatic postural responses may be gain control.</description><identifier>ISSN: 0022-3050</identifier><identifier>EISSN: 1468-330X</identifier><identifier>DOI: 10.1136/jnnp.65.5.734</identifier><identifier>PMID: 9810948</identifier><identifier>CODEN: JNNPAU</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd</publisher><subject>Adaptation ; Adult ; Aged ; Ataxia ; Biological and medical sciences ; Cerebellar Diseases - diagnosis ; cerebellum ; Electromyography - methods ; Female ; human ; Humans ; Male ; Medical sciences ; Middle Aged ; Muscle, Skeletal - innervation ; Nervous system (semeiology, syndromes) ; Nervous system as a whole ; Neurology ; Orthopedics ; Posture ; Predictive Value of Tests</subject><ispartof>Journal of neurology, neurosurgery and psychiatry, 1998-11, Vol.65 (5), p.734-742</ispartof><rights>Journal of Neurology, Neurosurgery, and Psychiatry</rights><rights>1998 INIST-CNRS</rights><rights>Copyright: 1998 Journal of Neurology, Neurosurgery, and Psychiatry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b510t-4e902b84417e4dc77284093331ed11ea0891136ca92beb083674481888e9832a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2170325/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2170325/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2423070$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9810948$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mummel, P</creatorcontrib><creatorcontrib>Timmann, D</creatorcontrib><creatorcontrib>Krause, U W H</creatorcontrib><creatorcontrib>Boering, D</creatorcontrib><creatorcontrib>Thilmann, A F</creatorcontrib><creatorcontrib>Diener, H C</creatorcontrib><creatorcontrib>Horak, F B</creatorcontrib><title>Postural responses to changing task conditions in patients with cerebellar lesions</title><title>Journal of neurology, neurosurgery and psychiatry</title><addtitle>J Neurol Neurosurg Psychiatry</addtitle><description>OBJECTIVE To investigate the role of the cerebellum in postural adaptation for changes to the stimulus type of support surface displacements (backward translations v“toes up” rotations). METHODS A group of 13 patients with chronic, isolated lesions of the cerebellum and 15 control subjects were tested. Automatic postural responses of the medial gastrocnemius and anterior tibial muscles were recorded. The first paradigm consisted of 10 rotational perturbations followed by 10 backward translations of the platform, and 10 backward translations followed by 10 rotations. The second paradigm consisted of 18 rotations and two randomly interposed translational perturbations, and 18 translations with two rotations randomly interposed. RESULTS When the type of perturbation changed from an expected translation to an unexpected rotation and vice versa both control subjects and cerebellar patients showed an immediate and significant change in the response amplitude of the medial gastrocnemius and at the same time an immediate and significant change in the response amplitude of the anterior tibial muscles. Neither controls nor cerebellar patients showed effects of prediction in surface displacements of unexpected types of perturbation. Both controls and cerebellar patients showed no gradual increase in the gastrocnemius response in subsequent trials of surface translations following a block of 10 surface rotations and no gradual increase in the response amplitude of the anterior tibial muscle in subsequent trials of surface rotations following a block of 10 surface translations. CONCLUSIONS Despite postural hypermetria, the integrity of the cerebellum does not seem critical for adaptation of postural synergies to changing stimulus types of surface displacements. The present results support previous findings suggesting that the main role of the cerebellum in automatic postural responses may be gain control.</description><subject>Adaptation</subject><subject>Adult</subject><subject>Aged</subject><subject>Ataxia</subject><subject>Biological and medical sciences</subject><subject>Cerebellar Diseases - diagnosis</subject><subject>cerebellum</subject><subject>Electromyography - methods</subject><subject>Female</subject><subject>human</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Muscle, Skeletal - innervation</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Nervous system as a whole</subject><subject>Neurology</subject><subject>Orthopedics</subject><subject>Posture</subject><subject>Predictive Value of Tests</subject><issn>0022-3050</issn><issn>1468-330X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkc-LEzEcxYO4rHX16FEIKOJlan5OMhdBBnUXyiq6ireQSdM23WkyJhl1_3sztAzqxVy-h_fh5T0eAE8wWmJM61d774dlzZd8KSi7BxaY1bKiFH27DxYIEVJRxNED8DClPZqebM7BeSMxaphcgE8fQ8pj1D2MNg3BJ5tgDtDstN86v4VZp1togl-77IoKnYeDzs76nOBPl3fQ2Gg72_c6wt6miXkEzja6T_bx6V6AL-_e3rSX1erD-6v2zarqOEa5YrZBpJOMYWHZ2ghBJEMNpRTbNcZWl6BTP6Mb0tkOSVoLxiSWUtpGUqLpBXh99B3G7mDXpmQqPdQQ3UHHOxW0U38r3u3UNvxQBAtECS8GL04GMXwfbcrq4JKZungbxqQEQgw3tSjgs3_AfRijL-UUFhJzjhtBClUdKRNDStFu5igYqamKmqZSNVdclakK__TP_DN92qboz0-6Tkb3m6i9cWnGCCMUlSLzty5l-2uWdbxVJbrg6vprq9obguTn65VqC__yyHeH_X8S_gaDBrjJ</recordid><startdate>19981101</startdate><enddate>19981101</enddate><creator>Mummel, P</creator><creator>Timmann, D</creator><creator>Krause, U W H</creator><creator>Boering, D</creator><creator>Thilmann, A F</creator><creator>Diener, H C</creator><creator>Horak, F B</creator><general>BMJ Publishing Group Ltd</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><general>BMJ Group</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19981101</creationdate><title>Postural responses to changing task conditions in patients with cerebellar lesions</title><author>Mummel, P ; Timmann, D ; Krause, U W H ; Boering, D ; Thilmann, A F ; Diener, H C ; Horak, F B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b510t-4e902b84417e4dc77284093331ed11ea0891136ca92beb083674481888e9832a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adaptation</topic><topic>Adult</topic><topic>Aged</topic><topic>Ataxia</topic><topic>Biological and medical sciences</topic><topic>Cerebellar Diseases - diagnosis</topic><topic>cerebellum</topic><topic>Electromyography - methods</topic><topic>Female</topic><topic>human</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Muscle, Skeletal - innervation</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Nervous system as a whole</topic><topic>Neurology</topic><topic>Orthopedics</topic><topic>Posture</topic><topic>Predictive Value of Tests</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mummel, P</creatorcontrib><creatorcontrib>Timmann, D</creatorcontrib><creatorcontrib>Krause, U W H</creatorcontrib><creatorcontrib>Boering, D</creatorcontrib><creatorcontrib>Thilmann, A F</creatorcontrib><creatorcontrib>Diener, H C</creatorcontrib><creatorcontrib>Horak, F B</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mummel, P</au><au>Timmann, D</au><au>Krause, U W H</au><au>Boering, D</au><au>Thilmann, A F</au><au>Diener, H C</au><au>Horak, F B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Postural responses to changing task conditions in patients with cerebellar lesions</atitle><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle><addtitle>J Neurol Neurosurg Psychiatry</addtitle><date>1998-11-01</date><risdate>1998</risdate><volume>65</volume><issue>5</issue><spage>734</spage><epage>742</epage><pages>734-742</pages><issn>0022-3050</issn><eissn>1468-330X</eissn><coden>JNNPAU</coden><abstract>OBJECTIVE To investigate the role of the cerebellum in postural adaptation for changes to the stimulus type of support surface displacements (backward translations v“toes up” rotations). METHODS A group of 13 patients with chronic, isolated lesions of the cerebellum and 15 control subjects were tested. Automatic postural responses of the medial gastrocnemius and anterior tibial muscles were recorded. The first paradigm consisted of 10 rotational perturbations followed by 10 backward translations of the platform, and 10 backward translations followed by 10 rotations. The second paradigm consisted of 18 rotations and two randomly interposed translational perturbations, and 18 translations with two rotations randomly interposed. RESULTS When the type of perturbation changed from an expected translation to an unexpected rotation and vice versa both control subjects and cerebellar patients showed an immediate and significant change in the response amplitude of the medial gastrocnemius and at the same time an immediate and significant change in the response amplitude of the anterior tibial muscles. Neither controls nor cerebellar patients showed effects of prediction in surface displacements of unexpected types of perturbation. Both controls and cerebellar patients showed no gradual increase in the gastrocnemius response in subsequent trials of surface translations following a block of 10 surface rotations and no gradual increase in the response amplitude of the anterior tibial muscle in subsequent trials of surface rotations following a block of 10 surface translations. CONCLUSIONS Despite postural hypermetria, the integrity of the cerebellum does not seem critical for adaptation of postural synergies to changing stimulus types of surface displacements. The present results support previous findings suggesting that the main role of the cerebellum in automatic postural responses may be gain control.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd</pub><pmid>9810948</pmid><doi>10.1136/jnnp.65.5.734</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adaptation Adult Aged Ataxia Biological and medical sciences Cerebellar Diseases - diagnosis cerebellum Electromyography - methods Female human Humans Male Medical sciences Middle Aged Muscle, Skeletal - innervation Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Orthopedics Posture Predictive Value of Tests |
| title | Postural responses to changing task conditions in patients with cerebellar lesions |
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