Critical role of hypoxia and A2A adenosine receptors in liver tissue-protecting physiological anti-inflammatory pathway

Whole body exposure of wild type control littermates and A2A adenosine receptor (A2AR) gene deleted mice to low oxygen containing inspired gas mixture allowed the investigation of the mechanism that controls inflammatory liver damage and protects the liver using a mouse model of T cell-mediated vira...

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Veröffentlicht in:	Molecular medicine (Cambridge, Mass.) Mass.), 2008-03, Vol.14 (3-4), p.116-123
Hauptverfasser:	Choukèr, Alexander, Thiel, Manfred, Lukashev, Dmitriy, Ward, Jerrold M, Kaufmann, Ines, Apasov, Sergey, Sitkovsky, Michail V, Ohta, Akio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - metabolism Adenosine A2 Receptor Antagonists Animals Concanavalin A - metabolism Cytokines - blood Hepatitis - metabolism Hepatitis - pathology Hepatitis - virology Humans Hypoxia Inflammation - metabolism Liver - metabolism Liver - pathology Mice Mice, Inbred C57BL Mice, Knockout Oxygen - blood Purines - blood Receptor, Adenosine A2A - genetics Receptor, Adenosine A2A - metabolism Signal Transduction - physiology T-Lymphocytes - immunology Triazines - metabolism Triazoles - metabolism
Online-Zugang:	Volltext
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