State-independent block of BK channels by an intracellular quaternary ammonium

Intracellular blockade by quaternary ammonium (QA) molecules of many potassium channels is state dependent, where the requirement for channel opening is evidenced by a time-dependent component of block in the macroscopic record. Whether this is the case for Ca(2+)- and voltage-activated potassium (B...

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Veröffentlicht in:	The Journal of general physiology 2006-09, Vol.128 (3), p.347-364
Hauptverfasser:	Wilkens, Christina M, Aldrich, Richard W
Format:	Artikel
Sprache:	eng
Schlagworte:	Ammonia Animals Benzophenones - metabolism Benzophenones - pharmacology Binding Sites - drug effects Cell Membrane Permeability - drug effects Cells Cyclic Nucleotide-Gated Cation Channels Ion Channel Gating - drug effects Ion Channel Gating - physiology Ion Channels - physiology Kinetics Large-Conductance Calcium-Activated Potassium Channel alpha Subunits - physiology Large-Conductance Calcium-Activated Potassium Channels - physiology Membrane Potentials Mice Oocytes - metabolism Patch-Clamp Techniques Permeability Potassium Potassium Channel Blockers - pharmacology Quaternary Ammonium Compounds - metabolism Quaternary Ammonium Compounds - pharmacology Time Factors Xenopus - metabolism
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