Different Dystrophin-Like Complexes Are Expressed in Neurons and Glia

Duchenne muscular dystrophy is a fatal muscle disease that is often associated with cognitive impairment. Accordingly, dystrophin is found at the muscle sarcolemma and at postsynaptic sites in neurons. In muscle, dystrophin forms part of a membrane-spanning complex, the dystrophin-associated protein...

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Veröffentlicht in:	The Journal of cell biology 1999-11, Vol.147 (3), p.645-657
Hauptverfasser:	Blake, Derek J., Hawkes, Richard, Benson, Matthew A., Beesley, Phillip W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies Brain Brain - cytology Brain - metabolism Cellular biology Cytoskeletal Proteins - metabolism Disease Dp71 protein Duchenne muscular dystrophy Dystrophin - analogs & derivatives Dystrophin - deficiency Dystrophin - genetics Dystrophin - metabolism Dystrophin-Associated Proteins Gene Deletion Immune Sera - immunology Membrane Proteins - deficiency Membrane Proteins - genetics Membrane Proteins - immunology Membrane Proteins - metabolism Mice Mice, Transgenic Molecular Sequence Data Muscle Proteins - metabolism Muscular Dystrophy, Duchenne - metabolism Muscular system Nerve Tissue Proteins - metabolism Neuroglia Neuroglia - metabolism Neurons Neurons - cytology Neurons - metabolism Original Postsynaptic density Protein Binding Protein isoforms Protein Isoforms - deficiency Protein Isoforms - genetics Protein Isoforms - immunology Protein Isoforms - metabolism Purkinje cells Rats Reaction products Solubility Synaptosomes Synaptosomes - metabolism Utrophin
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