Electrical and optical study of nerve impulse-evoked ATP-induced, P2X-receptor-mediated sympathetic neurotransmission at single smooth muscle cells in mouse isolated vas deferens

Abstract Simultaneous electrophysiology and confocal microscopy were used to investigate purinergic neurotransmission at single smooth muscle cells (SMCs) in mouse isolated vas deferens, and to explore the relationship between two high-resolution P2X-receptor-mediated measures of per pulse ATP relea...

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Veröffentlicht in:	Neuroscience 2007-08, Vol.148 (1), p.82-91
Hauptverfasser:	Young, J.S, Brain, K.L, Cunnane, T.C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Adenosine Triphosphate - pharmacology Adenosine Triphosphate - secretion Animals Biological and medical sciences calcium imaging Calcium Signaling - drug effects Calcium Signaling - physiology Cellular Neuroscience confocal microscopy discrete event EJP Electrophysiology - methods Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Fundamental and applied biological sciences. Psychology Male Mice Mice, Inbred BALB C Microscopy, Confocal Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism NCT Neurology Neurotransmitter Agents - metabolism Neurotransmitter Agents - secretion Organ Culture Techniques Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ Presynaptic Terminals - metabolism Presynaptic Terminals - secretion Receptors, Purinergic P2 - metabolism Receptors, Purinergic P2X Sympathetic Fibers, Postganglionic - drug effects Sympathetic Fibers, Postganglionic - metabolism Sympathetic Fibers, Postganglionic - secretion Synaptic Transmission - drug effects Synaptic Transmission - physiology Synaptic Vesicles - metabolism Synaptic Vesicles - secretion Time Factors Vas Deferens - innervation Vas Deferens - metabolism Vertebrates: nervous system and sense organs
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