S-Nitrosylation of Mitochondrial Caspases

Caspase-3 is a cysteine protease located in both the cytoplasm and mitochondrial intermembrane space that is a central effector of many apoptotic pathways. In resting cells, a subset of caspase-3 zymogens is S-nitrosylated at the active site cysteine, inhibiting enzyme activity. During Fas-induced a...

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Veröffentlicht in:	The Journal of cell biology 2001-09, Vol.154 (6), p.1111-1116
Hauptverfasser:	Mannick, Joan B., Schonhoff, Christopher, Papeta, Natalia, Ghafourifar, Pedram, Szibor, Marten, Fang, Kezhong, Gaston, Benjamin
Format:	Artikel
Sprache:	eng
Schlagworte:	Active sites Antibodies Apoptosis Caspase 3 Caspase 9 Caspases - metabolism Cell division Cell lines Cellular biology Cytochromes Enzyme Precursors - metabolism fas Receptor - pharmacology Humans Mitochondria Mitochondria - enzymology Mitochondria - metabolism Mitochondria - physiology Nitric Oxide Synthase - metabolism Oxides Physiological regulation Protein Sorting Signals Protein Transport Subcellular Fractions - enzymology Subcellular Fractions - metabolism Subcellular Fractions - physiology T lymphocytes Tumor Cells, Cultured Zymogens
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