Residual Cajal Bodies in Coilin Knockout Mice Fail to Recruit Sm snRNPs and SMN, the Spinal Muscular Atrophy Gene Product

Cajal bodies (CBs) are nuclear suborganelles involved in the biogenesis of small nuclear ribonucleoproteins (snRNPs). In addition to snRNPs, they are highly enriched in basal transcription and cell cycle factors, the nucleolar proteins fibrillarin (Fb) and Nopp140 (Nopp), the survival motor neuron (...

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Veröffentlicht in:	The Journal of cell biology 2001-07, Vol.154 (2), p.293-307
Hauptverfasser:	Tucker, Karen E., Berciano, Maria Teresa, Jacobs, Erica Y., LePage, David F., Shpargel, Karl B., Rossire, Jennifer J., Edward K. L. Chan, Lafarga, Miguel, Conlon, Ronald A., Matera, A. Gregory
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Autoantigens - metabolism Blotting, Northern Cell Line Cell lines Cell nucleolus Cell Nucleolus - metabolism Cell Nucleolus - ultrastructure Cells Cellular biology Chromosomal Proteins, Non-Histone - metabolism Coiled bodies Coiled Bodies - genetics Coiled Bodies - metabolism Coiled Bodies - ultrastructure Cyclic AMP Response Element-Binding Protein Exons Fetal Viability - genetics Gene Expression - drug effects Gene Targeting Green Fluorescent Proteins HeLa cells Homozygote Luminescent Proteins - genetics Mice Mice, Knockout - genetics Nerve Tissue Proteins - metabolism Nuclear Proteins - biosynthesis Nuclear Proteins - deficiency Nuclear Proteins - genetics Nuclear Proteins - metabolism Organ Specificity Phosphoproteins - metabolism Proteins Recombinant Fusion Proteins - biosynthesis Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - pharmacology Ribonucleoproteins, Small Nuclear - metabolism RNA Splicing RNA, Messenger RNA-Binding Proteins Rodents Small nuclear ribonucleoproteins SMN Complex Proteins snRNP Core Proteins Spine Splicing Survival Rate
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