In Vitro Assembly and Structure of Trichocyte Keratin Intermediate Filaments: A Novel Role for Stabilization by Disulfide Bonding

Intermediate filaments (IF) have been recognized as ubiquitous components of the cytoskeletons of eukaryotic cells for 25 yr. Historically, the first IF proteins to be characterized were those from wool in the 1960s, when they were defined as low sulfur keratins derived from "microfibrils."...

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Veröffentlicht in:	The Journal of cell biology 2000-12, Vol.151 (7), p.1459-1468
Hauptverfasser:	Wang, He, David A. D. Parry, Jones, Leslie N., Idler, William W., Marekov, Lyuben N., Steinert, Peter M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Cell Differentiation Cellular biology Chemical bonding Chromatography, High Pressure Liquid Disulfides Disulfides - metabolism Experiments Hair Humans Intermediate filaments Intermediate Filaments - chemistry Intermediate Filaments - metabolism Intermediate Filaments - ultrastructure Keratins Keratins - chemistry Keratins - classification Keratins - metabolism Keratins - ultrastructure Least-Squares Analysis Mice Microscopy, Electron Molecular Sequence Data Molecules Oligomers Original Oxidation-Reduction Protein Structure, Quaternary Protein Structure, Tertiary Reagents Sequence Alignment Wool Wool - chemistry Wool - cytology X ray diffraction
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